Much research has attempted to show direct linear relations between
genes and disorder. However, scientists have been discouraged by
inconsistent findings based on this simple gene-phenotype approach.
The alternative approach is to incorporate information about the
environment. A gene-environment interaction approach assumes that
environmental pathogens cause disorder, whereas genes influence
susceptibility to environmental pathogens.
This book brings together contributions from experts from
multiple disciplines who discuss:
* How epidemiological cohort studies can better integrate
physiological (mechanistic) measures;
* How best to characterise subjects’ vulnerability versus
resilience by moving beyond single genetic polymorphisms;
* How gene hunters can benefit from recruiting samples selected
for known exposures;
* How environmental pathogens can be used as tools for gene
hunting;
* How to deal with potential spurious (statistical) interactions,
and
* How genes can help explain fundamental demographic properties
of disorders (e.g. sex distribution, age effects).
Mục lục
1. Michael Rutter
Introduction: whither gene-environment interactions?
2. Rudolf Uher
Gene-environment interaction: overcoming methodological
challenges
Discussion
3. Marco Battaglia, Cecilia Marino, Michel Maziade, Massimo
Molteni and Francesca D’Amato
Gene-environment interaction and behavioural disorders: a
developmental perspective based on endophenotypes
Discussion
4. Naomi R. Wray, William L. Coventry, Michael R. James,
Grant W. Montgomery, Lindon J. Eaves and Nicholas G.
Martin
Use of monozygotic twins to investigate the relationship between
5HTTLPR genotype, depression and stressful life events: an
application of Item Response Theory
Discussion
Appendix
General discussion I
5. Harold Snieder, Xiaoling Wang, Vasiliki Lagou, Brenda W.
J. H. Penninx, Harriëtte Riese and Catharina A.
Hartman
Role of gene-stress interactions in gene-finding
studies
Discussion
6. Kenneth A. Dodge
Practice and public policy in the era of gene-environment
interactions
Discussion
7. Kristi B. Adamo and Frédérique
Tesson
Gene-environment interaction and the metabolic
syndrome
Discussion
General discussion II
8. Stephen P. Robertson and Richie
Poulton
Longitudinal studies of gene-environment interaction in
common diseases–good value for money?
Discussion
9. Kee-Seng Chia
Gene-environment interactions in breast cancer
Discussion
10. Malak Kotb, Nourtan Abdeltawab, Ramy Aziz, Sarah
Rowe, Robert W. Williams and Lu Lu
Unbiased forward genetics and systems biology approaches to
understanding how gene-environment interactions work to
predict susceptibility and outcomes of infections
Discussion
11. Steven R. Kleeberger and Hye-Youn
Cho
Gene-environment interactions in environmental lung
diseases
Discussion
General discussion III
12. Fernando D. Martinez
Gene-environment interaction in complex diseases: asthma
as an illustrative case
Discussion
13. Michael Rutter
Conclusions: taking stock and looking ahead
Glossary
Index of contributors
Subject index
Giới thiệu về tác giả
Prof Sir Michael Rutter, King’s College, London, UK
Prof Rutter is the leading child psychiatrist in the UK. He set up the MRC Child Psychiatry Research Unit and the Institute of Psychiatry’s Social, Genetic and Developmental Psychiatry Centre. He was Deputy Chairman of the Wellcome Trust from 1999 to 2004, and has been a Trustee of the Nuffield Foundation since 1992. He was elected a Fellow of the Royal Society in 1987 and an honorary member of the British Academy in 2002.?He was a Founding Fellow of the Academia Europaea and the Academy of Medical Sciences, of which he is currently Clinical Vice-President.
He has published extensively.
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