The DNA of all organisms is constantly being damaged by endogenous and exogenous sources. Oxygen metabolism generates reactive species that can damage DNA, proteins and other organic compounds in living cells. Exogenous sources include ionizing and ultraviolet radiations, carcinogenic compounds and environmental toxins among others. The discovery of multiple DNA lesions and DNA repair mechanisms showed the involvement of DNA damage and DNA repair in the pathogenesis of many human diseases, most notably cancer. These books provide a comprehensive overview of the interdisciplinary area of DNA damage and DNA repair, and their relevance to disease pathology. Edited by recognised leaders in the field, this two-volume set is an appealing resource to a variety of readers including chemists, chemical biologists, geneticists, cancer researchers and drug discovery scientists.
Mục lục
Biomonitoring of DNA Damage in Humans; Tandem and Clustered Lesions from Radicals in Nucleic Acids from a Single Initial Chemical Event; Oxidative DNA Damage and Repair in G-Quadruplexes; Oxidatively Induced DNA Damage: Mechanisms and Measurement; Oxidation of the C5′ Position in DNA and the Role of Purine 5′, 8-Cyclo-2′-deoxynucleoside Lesions; Ferroptosis and Oxidative DNA Damage; DNA-Protein Cross-Links: Formation, Genotoxicity and Repair; Substrate Specificities of DNA Glycosylases in vitro and in vivo; Special Problems for Base Excision Repair in Coping with Oxidatively-induced DNA Damage; Genomic Uracil in Biology, Immunity and Cancer; Alternative DNA Repair Pathways to Handle Complex DNA Damage Generated by Oxidative Stress and Anticancer Drugs; Redox Stress Responses and Human Disease: NTHL1 at the Intersection of DNA Damage Repair and Cancer; Emerging Roles of Non-Canonical RNA Binding Proteins in Repair of Genome Damage Linked to Human Pathologies; Modulation of DNA Glycosylase Activities via Small Molecules; DNA Repair in the Development of Human Diseases and Therapy;
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