From pathology to treatment, Micro RNAs in Diseases and Disorders highlights the role of micro RNAs (mi RNAs) in the development and progression of a variety of diseases, including cancer, neurological disease, endocrine disease and autoimmune disease, and underscores the utilization of mi RNA targets in the treatment of these conditions. Providing a comprehensive account, this book also includes the identification of mi RNAs as diagnostic and prognostic biomarkers for disease, as well as evaluates translational value from clinical trials using synthesized and functionalized mi RNA mimics and inhibitors.
With a global contribution list and chapters from leading experts across the field, Micro RNAs in Diseases and Disorders is an invaluable reference to mi RNA researchers and health professionals in a variety of disease areas in government, academia and industry. The book will also appeal to pharmaceutical and medicinal chemists with an interest in mi RNA targeting therapeutics, as well as to advanced students in chemical biology and drug discovery.
Mục lục
Role of Nutrition, the Epigenome, and Micro RNAs in Cancer Pathogenesis; Role of Micro RNAs in Metabolic Diseases; Circulating Micro RNAs as Biomarkers of Coeliac Disease and Other Intestinal Pediatric Diseases – Experimental and Bioinformatics Challenges from the Bench to the Bedside; Micro RNAs and Mycobacterial Infections in Humans and Domestic Animals; Regulation and Function of Micro RNAs in Kidney Diseases; Involvement of Micro RNAs in Autoimmune Diseases; Micro RNAs in Ischemic Stroke, Hemorrhagic Stroke, and Traumatic Brain Injury; Micro RNAs as Biomarkers for Neurological Disorders; Micro RNAs in Endocrine Disorders; Micro RNAs in Skin Development, Function and Disorders; Micro RNAs in Haematological Diseases; Discovery and Therapeutic Relevance of Small Molecule Modifiers of Micro RNA Function; Micro RNA-specific Argonaute 2 Protein Inhibitors and AGO Loading Inhibitors; Strategies for Safe and Targeted Delivery of Micro RNA Therapeutics; Modification of Drug Response in Cancer by Micro RNAs; Nanoparticle Delivery of Mi RNA in Cancer
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