This cutting-edge, interdisciplinary volume describes established and state of the art approaches for exploring the pathways that influence and control appetite, including: behavioural, electrophysiological, neuroanatomical, gene knockout and pharmacological techniques. The book presents key peptide and neurotransmitter systems, together with newly emerging concepts of metabolic signalling and hypothalamic inflammation. The impact of early life experience on neuroendocrine appetite circuits is also looked at, including early programming of these circuits by circulating hormones. Finally, new emerging therapeutic approaches to appetite suppression are discussed, including those linked to bariatric (weight loss) surgery.
Neuroendocrinology of Appetite is especially focused on established and emerging technologies and approaches for investigating appetite control. It is written so as to provide an overview of sufficient depth for an undergraduate or new scientist in the field to come up to speed in the complementary approaches used by researchers in this field. Taking an interdisciplinary approach, the book aims to appeal to all those with a basic, clinical or therapeutic interest in research into obesity and eating disorders.
Mục lục
Foreword vii
List of Contributors ix
Series Preface xi
About the Companion Website xiii
1 Neuroanatomy of Feeding Pathways 1
Brian J. Oldfield, Paul N. Mirabella, and Aneta Stefanidis
2 Afferent Endocrine Control of Eating 24
Wolfgang Langhans and Jens Juul Holst
3 Ontogeny of Neuroendocrine Feeding Circuits 55
Sophie Croizier and Sebastien G. Bouret
4 Hypothalamic Peptides and Meal Patterns 76
Yada Treesukosol and Timothy H. Moran
5 Food Hedonics: Insight from Animal Models 90
Karolina P. Skibicka and Scott E. Kanoski
6 Functional and Anatomical Dissection of Feeding Circuits 112
Deniz Atasoy and Scott M. Sternson
7 Exploring Appetite and Hypothalamic Circuitry through Manipulating Gene Expression 134
Tara Jois and Mark W. Sleeman
8 Electrophysiology of the Appetite-Regulating Circuits of the Hypothalamus 151
Nancy Sabatier, John Menzies, and Gareth Leng
9 Functional Neuroimaging of Appetite and Gut-Brain Interactions 174
Paul A.M. Smeets and Hubert Preissl
10 Appetite Disorders: From Binge Eating to Anorexia Nervosa 201
Mathieu Méquinion, Susanne la Fleur, and Odile Viltart
11 Future Prospects of the Management of Appetite Disorders Bariatric Surgery 224
Carel le Roux and Karl Neff
12 Discovery of New Drugs for Weight Loss and Prevention of Weight Regain 247
Anders Lehmann, Udo Bauer, Stephan Hjorth, Rudolph L. Leibel and Michael Rosenbaum
Index 000
Giới thiệu về tác giả
Professor Suzanne L Dickson, The Sahlgrenska Academy of the University of Gothenberg, Sweden
Professor Julian G. Mercer, Rowett Institute of Nutrition and Health, University of Aberdeen, UK
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