The two volumes ‘Science of Synthesis: Multicomponent Reactions’ critically review the state of the art of domino, sequential, and consecutive multicomponent reactions in what is a highly dynamic field. They serve as the basis for practical application to reach the goals of diversity-oriented synthesis, reaction design, and novel synthetic concepts. As is typical for the Science of Synthesis series, the reference work on multicomponent reactions presents the best synthetic methods as judged by experts in the field and includes typical and general experimental procedures.
The volume ‘Reactions Involving a Carbonyl Compound as Electrophilic Component’ covers the following topics:
- Biginelli Reaction
- Strecker Reaction
- Hantzsch Pyridine Synthesis
- Mannich Reaction
- Petasis Reaction
- Willgerodt-Kindler Reaction
- Kabachnik-Fields Reaction
- Passerini Reaction
- Ugi Reaction
- Gewald Reaction
Mục lục
<p>1.1 Relative Reactivities of Functional Groups as the Key to Multicomponent Reactions<br>1.2.1.1 Third Component 1, 3-Dicarbonyl Compound (with Ureas: Biginelli Reaction)<br>1.2.1.2 Third Component 1, 3-Dicarbonyl Compound (with Ammonia or Amines: Hantzsch Pyridine Synthesis)<br>1.2.1.3 Third Component Cyanide (Strecker and Strecker-Type Reactions)<br>1.2.1.4 Third Component Enolizable Carbonyl Compound (Mannich Reaction)<br>1.2.1.5 Third Component Metal Alkyl or Aryl<br>1.2.1.6 Third Component Alkyne<br>1.2.1.7 Third Component Boronic Acid (Petasis Reaction)<br>1.2.1.8 Third Component Sulfur (Willgerodt–Kindler Reaction)<br>1.2.1.9 Third Component Phosphonate (Kabachnik–Fields Reaction)<br>1.2.2 With an Enamine as One Component<br>1.2.3.1 Third Component Carboxylic Acid (Passerini Reaction)<br>1.2.3.2 Further Components Carboxylic Acid and Amine (Ugi Reaction)<br>1.2.3.3 Modifications of the Ugi Reaction<br>1.2.4 Using a Nitrile and Sulfur as Nucleophiles (Gewald Reaction)</p>
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