The manipulation of cells and microparticles within microfluidic systems using external forces is valuable for many microscale analytical and bioanalytical applications. Acoustofluidics is the ultrasound-based external forcing of microparticles with microfluidic systems. It has gained much interest because it allows for the simple label-free separation of microparticles based on their mechanical properties without affecting the microparticles themselves.
Microscale Acoustofluidics provides an introduction to the field providing the background to the fundamental physics including chapters on governing equations in microfluidics and perturbation theory and ultrasound resonances, acoustic radiation force on small particles, continuum mechanics for ultrasonic particle manipulation, and piezoelectricity and application to the excitation of acoustic fields for ultrasonic particle manipulation. The book also provides information on the design and characterization of ultrasonic particle manipulation devices as well as applications in acoustic trapping and immunoassays.
Written by leading experts in the field, the book will appeal to postgraduate students and researchers interested in microfluidics and lab-on-a-chip applications.
Mục lục
Governing equations in microfluidics; Regular perturbation theory for acoustic fields; Linear continuum mechanics; Linear piezoelectric transducers; Building microfluidic acoustic resonators; Experimental characterization of devices; Acoustic radiation force; Applications in acoustophoresis; Modelling and applications of planar resonant devices; Scaling-laws and time scales in acoustofluidics; Affinity acoustophoresis; Biocompatibility and cell viability in microfluidic acoustic resonators; Analysis of acoustic streaming by singular perturbation; Applications in acoustic streaming; Streaming with ultrasound waves interacting with solid particles; Acoustics streaming near liquid-gas interfaces: drops and bubbles; SAW devices; Microscopy for lab-on-a-chip devices; Particle manipulation in acoustic cavities; Applications in acoustic trapping; Enhanced immunoassays and particle sensors; Multiwavelength devices and scale dependent properties; Acoustic manipulation combined with other techniques
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