An illuminating summary of our current understanding of the interactive role of dopamine and glutamate in psychiatric diseases and the therapeutic strategies and possibilities for future treatment. Among the new ideas presented are hypotheses on the role of dopamine and glutamate in aggression, the glutamate system in anxiety disorders, glutamate and neurodegeneration, and on the origin and progression of Parkinson’s disease. Additional chapters offer novel insights into a variety of psychiatric diseases, including ADHD, stress, aggression, addiction, schizophrenia, depression, social phobias, dementias, bulimia, and neurodegenerative diseases like Parkinson’s and Alzheimer’s diseases. Each chapter summarizes the prevalence and symptoms of the disease and explains the involvement of dopamine and/or glutamate systems using the newer molecular approaches such as transgenic knockout or knockin mice and recent brain imaging techniques.
Mục lục
Dopamine.- Dopamine Receptors.- Dopamine Receptor Alternative Splicing.- Glutamate.- Glutamatergic Pathways.- Glutamate Receptors.- Metabotropic Glutamate Receptors.- Schizophrenia.- Dopamine and Schizophrenia.- Glutamate and Schizophrenia and the N-Methyl-d-Aspartate Receptor Hypofunction Hypothesis.- Role of Glycine in Schizophrenia.- Depression.- Dopamine and Depression.- Glutamate and Depression.- Stress and Aggression.- Dopamine, Glutamate, and Aggression.- Anxiety.- Glutamatergic Systems and Anxiety.- Attention Deficit Hyperactivity Disorder.- Dopamine and Glutamate in Attention Deficit Hyperactivity Disorder.- Addiction.- Dopamine-Glutamate Interactions in Reward-Related Incentive Learning.- Sensitization and Relapse.- Glutamatergic Neurotransmission in Sensitization.- Glutamatergic Mechanisms of Drug Relapse.- Neurodegeneration.- Dopamine and Neurodegeneration.- Glutamate and Neurodegeneration.- Parkinson’s Disease.- Presymptomatic and Symptomatic Stages of Intracerebral Inclusion Body Pathology in Idiopathic Parkinson’s Disease.- Dopamine and Glutamate in Parkinson’s Disease.- Dopamine and Glutamate in Motor and Cognitive Symptoms of Parkinson’s Disease.- Huntington’s Disease.- Dopamine and Glutamate in Huntington’s Disease.- Dementias.- Dopaminergic and Glutamatergic Systems in Alzheimer’s Disease.
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