Heavy metals essential to organisms are termed “biometals”. Bio-inorganic chemistry deals with the functions of biometals in vivo at an atomic to molecular level, while cellular regulation of biometals such as absorption and transport has been investigated in cell biology. Although these research fields have independently developed and matured, interdisciplinary information across these fields is required for a comprehensive understanding of the roles of biometals at atomic to molecular, cellular and organism levels.
Focusing on the biological significance of copper in our bodies, this book considers the maintenance of copper from different perspectives ranging from bio-inspired catalysts and mechanisms of copper proteins to pathological roles in diseases. Both quantity and quality of copper inside and outside the cell are essential for our health. Because of its high redox activity, copper acts as an active site for electron transfer and enzyme reactions in many proteins. Genetic and environmental disorders of copper metabolism are therefore associated with many diseases. In addition, copper-containing proteins are involved in the activation of molecular oxygen and have served as a good model for the development of inorganic copper complexes for industrial applications.
Resulting from a 5-year project on Integrated Biometal Science in Japan, this book not only documents the latest research but also fills a gap between chemical understanding and our real life.
Mục lục
- Structure and Function of Cu/Zn-superoxide Dismutase
- Structure and Function of Dinuclear Copper Tyrosinase
- Structure and Catalytic Mechanism of Copper/TPQ-containing Amine Oxidase
- Reaction Mechanism of Cytochrome c Oxidase
- Copper Chaperones and Copper Transporters in Health and Disease
- Multicopper Oxidase
- Wilson Disease, Crime of Copper
- Menkes Disease: The Pathological Mechanisms
- Clinical Features of Copper Deficiency
- Pathological Role of Copper and Cu, Zn-superoxide Dismutase (SOD1) in Amyotrophic Lateral Sclerosis (ALS)
- Canine Degenerative Myelopathy Caused by Mutations in the Cu2+/Zn2+ Superoxide Dismutase 1 Gene
- Down Syndrome-related Copper Disturbance in the Brain
- Copper Metabolism in Cancer Development and Therapy
- Blue Copper Protein Model Complexes
- Copper-based Superoxide Dismutase Enzyme Mimics: From Functional Models to Nanozymes
- Molecular Mechanism of Phenolase Activity of Tyrosinase
- Copper Complexes for Theranostics: From PET Imaging to Therapy
- Cancer-cell-selective Cytotoxicity of Dicopper Complexes with Various Amide-tether Dinucleating Ligands
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