Heavy metals essential to organisms are termed “biometals”. Bio-inorganic chemistry deals with the functions of biometals in vivo at an atomic to molecular level, while cellular regulation of biometals such as absorption and transport has been investigated in cell biology. Although these research fields are independently developed and matured, interdisciplinary information across these fields is required for a comprehensive understanding of the roles of biometals at atomic to molecular, cellular and organism levels.
This book focuses on iron (Fe) in cells, since it is the most abundant metal in living system and is involved in a variety of physiological events such as enzymatic reactions as catalysts and signal transduction. Both excess and shortage of iron cause serious diseases such as anaemia, cancer and neuronal degeneration. The cellular systems consisting of many specific proteins strictly control the iron contents through the iron dynamics in cells including absorption, sensing, storage, transport and usage.
Resulting from a 5-year project on Integrated Biometal Science in Japan, this book not only documents the latest research but also fills a gap between chemical understanding and our real life, by providing fundamental ideas on genetics, drugs and environmental health.
Table of Content
- Introduction to Iron Dynamics in Human Cells: Fundamental Mechanisms and Their Updates
- Role of Iron in Neoplastic Diseases
- Ferroptosis: An Iron-dependent Nonapoptotic Cell Death
- Non-alcoholic Steatohepatitis: Pathophysiologic Role of Iron in Liver Fibrosis
- An Attempt to Develop a Bacterial Growth Inhibitor Focusing on the Mechanism of Heme-iron Acquisition
- Iron Absorption in Human Duodenum by Dcytb and DMT1
- Regulatory Systems of Iron Homeostasis in Human Cells, Especially Focusing on IRPs
- Molecular Mechanisms of ABC Transporters Involved in Bacterial Heme Uptake and Efflux
- Proteins Related to Heme Catabolism for Iron Utilization and Other Functions in Mammals and Photosynthetic Organisms
- Allosteric Regulation of Heme-containing Respiratory Enzymes for Treatment: Cytochrome Oxidases and Nitric Oxide Reductases
- Proteins Related to Iron Deficiency Responses and Iron Sensing in Plant Cells
- Iron-phytosiderophore and Its Uptake Mechanism from the Soil
- Iron Complexes as Bio-inspired Catalysts for Efficient and Selective Oxidation of Organic Compounds
- Development of Novel Catalyst of the Oxygenase Reactions Using Artificial Iron-containing Enzymes
- Biomimetic Metal–Sulfur Clusters for N2 Activation and Reduction
- Visualization of Labile Iron and Heme in Living Cells
- Artificial Hemoglobin: Deployment of Cyclodextrin-heme Complexes into Medical Field
- Time-resolved Techniques for Characterization of Short-lived Intermediates in Catalytic Reaction of Iron-containing Proteins
- MD Simulation Reveals Inhibition Mechanism of Iron-containing Proteins: Case Studies
- Statistical Insight into Heme Structure and Its Variational Utility in Protein
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