A. Douglas Kinghorn & Heinz Falk 
Progress in the Chemistry of Organic Natural Products 115 [PDF ebook] 

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This book describes current understandings and recent progress into a varied group of natural products. In the first chapter the role that total synthesis may play in revising the structures proposed for decanolides, which are ten-membered lactones found primarily in fungi, frogs, and termites is presented. The following chapter presents the development of the intriguing plant-derived sesquiterpene lactone, thapsigargin, a potent inhibitor of the enzyme, SERCA (sarco-endoplasmic Ca
2+ ATPase), which has potential as a lead compound to treat cancer. The third chapter covers the potential of various plant phenolic compounds for treating the tropical and sub-tropical infectious disease, leishmaniasis. In addition the volume presents recent advances related to the plant alkaloid, cryptolepine, which is of particular interest as a lead for the treatment of malaria, trypanosomiasis, and cancer.

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表中的内容

Total Synthesis of Decanolides (Nonanolides) with a Special Focus on Olefin Metathesis.- From Plant to Patient: Thapsigargin.- Antileishmanial Activity of Lignans and Neolignans.- Cryptolepine as a Lead to new Antiprotozoal Agents.- Biologically Active Constituents from Plants of the Genus Xanthium.

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语言 英语 ● 格式 PDF ● 网页 203 ● ISBN 9783030648534 ● 文件大小 10.6 MB ● 编辑 A. Douglas Kinghorn & Heinz Falk ● 出版者 Springer International Publishing ● 市 Cham ● 国家 CH ● 发布时间 2021 ● 下载 24 个月 ● 货币 EUR ● ID 7797899 ● 复制保护 社会DRM

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