The past two decades have seen an increasing emphasis on large and interdisciplinary research configurations such as research networks, and centers of excellence including those in Social Sciences and Humanities research. Little research has been undertaken, however, to understand how these new large research structures that are being called forth by research funders and research/higher education institutions alike function socially, and what the impact of operating within such structures is on those working within, and those working with, them. Past writers have discussed the ‘intra-agentic’ operations of human researchers and the material laboratory environment in its broadest sense. This volume is concerned with the social politics of research collaboration in relation to six key positions: leaders of large research formations, leaders of sub-projects within large collaborations, participant researchers, junior and early career researchers, advisory board members, and those who look in from the outside such as researchers who are un-funded. It explores the mostly unacknowledged but critical aspect of social structures in research, discussing issues such as struggles over leadership styles, the marginalization of researchers working cross-disciplinarily, power hierarchies and intellectual ownership, and the silencing of dissent in research.