This book discusses the latest advances in chemistry research. Chapter 1 summarizes the current state of C-scorpionate coordination chemistry, exploring the synthesis of their metal complexes and the exciting array of applications that these compounds have unlocked. Chapter 2 discusses the charge-transfer (CT) reactivity in A(acid)B(base) systems and how it is approached in both the gas-phase and on catalytic surface. Chapter 3 covers information on fundamental knowledge on ligand-protein interaction and how it can be utilized to design a variety of new aggregation inhibitors and anti-amyloid therapeutics. Chapter 4 introduces the successful drug discovery process that includes not only optimization of drug-biological receptor interactions but also efficient delivery to the site of action by means of crossing biomembranes. Chapter 5 discusses how drugs on the pharmaceutical market use hydrophobic poorly soluble substances to successfully distribute into the body. Chapter 6 is aimed at determining the influence of coal charge grindability on the scheme of preparing coal for coking by optimizing the operation of the crushing department.