From large cross-sectional studies of autopsy material, it seems as if a time course of Alzheimer’s Disease, at least on average, can be mapped out: a pattern of hierarchical vulnerability for neuronal loss and neurofibrillary tangles beginning in medial temporal lobe structures proceeding through association areas. Plaques follow their own temporal course, with widespread cortical deposits occurring even early in a disease process. The whole process may well take twenty years, the first half of which may be without overt symptoms.
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语言 英语 ● 格式 PDF ● ISBN 9783642593000 ● 编辑 Jean-Francois Demonet & Bradley T. Hyman ● 出版者 Springer Berlin Heidelberg ● 发布时间 2012 ● 下载 3 时 ● 货币 EUR ● ID 6380256 ● 复制保护 Adobe DRM
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