A compendium of proven experimental approaches and strategies for studying the bioactivation, detoxification, tissue distribution, and elimination of xenobiotics in the metabolism and/or transport of various chemicals. The authors address several of the major drug metabolizing systems, including the cytochrome P450 family, flavin-containing monooxygenases, glutathione, S-transferase, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy.
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语言 英语 ● 格式 EPUB ● ISBN 9781592598328 ● 编辑 Lawrence H. Lash ● 出版者 Humana Press ● 发布时间 2008 ● 下载 3 时 ● 货币 EUR ● ID 8839589 ● 复制保护 Adobe DRM
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