This text provides a solid understanding of the various statistical topics relevant to the design, monitoring, and analysis of a clinical trial. It covers basic experimental design, sample size, randomization procedures, interim and survival analyses, quality of life assessment, and longitudinal methods. The book describes all phases of a clinical trial and explores the advantages of and objections to the intent-to-treat principle as well as its implementation. With exercises at the end of most chapters, it also illustrates methods using examples with real data from a variety of disease areas, including heart and lung diseases, cancer, and AIDS.
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语言 英语 ● 格式 PDF ● 网页 464 ● ISBN 9781420009965 ● 编辑 Thomas D. Cook & David L. DeMets ● 出版者 CRC Press ● 发布时间 2007 ● 下载 3 时 ● 货币 EUR ● ID 7123367 ● 复制保护 Adobe DRM
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