This issue of Clinics in Chest Medicine, edited by Drs. Peter Marshall and Wassim Fares, focuses on Pulmonary Embolism, with topics including: Clinical Probability Tools for DVT, PE, & Bleeding; Prevention of DVTs and Pulmonary Emboli: General Measures and High-Risk Populations; Diagnosis of DVTs and PEs: New Imaging Tools and Modalities; Perfusion Defects Misdiagnosed as Pulmonary Emboli; The Vicious Cycle of Hypercoagulability and Pulmonary Hypertension; VTE in Special Populations; Preganncy and Thrombo-embolic Disease; Challenges and Changes to the Management of PE in the Emergency Department; The Value of Bedside Echocardiogram in the Setting of Acute & Chronic Pulmonary Embolism; Management of Low-Risk PE; Update on the ‘Novel’ and Direct Oral Anticoagulants; Risk Stratification: Definitive/Aggressive Treatment of Hemodynamically Stable but Intermediate Risk Patients; Pulmonary Embolism Response Team (PERT); Surgical and Other Interventions for DVTs; IVC Filters; Catheter-Based Therapies of Pulmonary Emboli; Surgical-Based Therapies for PEs; and Chronic Thrombo-embolic Pulmonary Hypertension (CTEPH).