Due to sensitive molecular biological techniques, our understanding of chromosomal aberrations is steadily increasing. Provided here is a review of basic and applied aspects of the field. Chromosome structure, induction of DNA lesions by different clastogenic agents and their repair, induction of aberrations by agents which affect specific sequences in the DNA, and factors affecting induction and yield of chromosomal aberrations are covered. Further, topics such as automation of aberration scoring, problems associated with using chromosomal aberrations and micronuclei in population monitoring and the importance of chromosomal aberration assays in mutagenicity testing of chemicals are included.
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Language English ● Format PDF ● ISBN 9783642788871 ● Editor Adayapalam T. Natarajan & Gunter Obe ● Publisher Springer Berlin Heidelberg ● Published 2012 ● Downloadable 3 times ● Currency EUR ● ID 6381975 ● Copy protection Adobe DRM
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