Presents the most effective catalytic reactions in use today, with a special focus on process intensification, sustainability, waste reduction, and innovative methods
This book demonstrates the importance of efficient catalytic transformations for producing pharmaceutically active molecules. It presents the key catalytic reactions and the most efficient catalytic processes, including their significant advantages over compared previous methods. It also places a strong emphasis on asymmetric catalytic reactions, process intensification (PI), sustainability and waste mitigation, continuous manufacturing processes as enshrined by continuous flow catalysis, and supported catalysis.
Active Pharmaceutical Ingredients in Synthesis: Catalytic Processes in Research and Development offers chapters covering: Catalysis and Prerequisites for the Modern Pharmaceutial Industry Landscape; Catalytic Process Design – The Industrial Perspective; Hydrogenation, Hydroformylation and Other Reductions; Oxidation; ; Catalytic Addition Reactions; Catalytic Cross-Coupling Reactions; Catalytic Metathesis Reactions; Catalytic Cycloaddition Reactions: Coming Full-Circle; Catalytic Cyclopropanation Reactions; Catalytic C-H insertion Reactions; Phase Transfer Catalysis; and Biocatalysis.
-Provides the reader with an updated clear view of the current state of the challenging field of catalysis for API production
-Focuses on the application of catalytic methods for the synthesis of known APIs
-Presents every key reaction, including Diels-Alder, CH Insertions, Metal-catalytic coupling-reactions, and many more
-Includes recent patent literature for completeness
Covering a topic of great interest for synthetic chemists and R&D researchers in the pharmaceutical industry, Active Pharmaceutical Ingredients in Synthesis: Catalytic Processes in Research and Development is a must-read for every synthetic chemist working with APIs.
Table of Content
Catalysis and Prerequisites for the Modern Pharmaceutial Industry Landscape
Catalytic Process Design – The Industrial Perspective
Hydrogenation, Hydroformylation and Other Reductions
Oxidation: Nobel Prize Chemistry Catalysis
Catalytic Addition Reactions
Catalytic Cross-Coupling Reactions – Nobel Prize Catalysis
Catalytic Metathesis Reactions – Nobel Prize Catalysis
Catalytic Cycloaddition Reactions: Coming Full-Circle
Catalytic Cyclopropanation Reactions
Catalytic C-H insertion Reactions
Phase Transfer Catalysis
Biocatalysis: Nobel Prize Catalysis
About the author
Anthony J. Burke, Ph D, is Professor at the University of Evora, and the coordinator of the organic and organometallic research line at the Centro de Química de Evora.
Carolina S. Marques, Ph D, is working as a Post Doc in the Burke group.
Nicholas Turner, Ph D, is Professor of Chemical Biology, Director of the Centre of Excellence in Biocatalysis (Co EBio3) and co-Director of SYNBIOCHEM.
Gesine J. Hermann, Ph D, is a research and business consultant for Chira Tecnics, Portugal.
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