Chemoprevention of cancer has been the focus of intensive research for more than two decades. Epidemiological evidence has shown a small, but significant association between fruit and vegetable intake and a reduction in cancer risk. Diet may account for about thirty five percent of cancer. Large claims have been made for the effectiveness of particular diets in determining one’s risk of developing cancer, ranging from protection against cancer initiation, progression and metastasis. A wide array of dietary components has been demonstrated to be as effective in fighting off cancer. Towards an increased understanding of the nutrition, excercise and diet in preventing cancer or inhibiting its progression has led to the discovery and development of novel and effective drugs that regulate intracellular signaling network in the body. This information will be very useful to explore novel and highly effective chemopreventive strategies for reducing the health burden of cancer. Hippocrates, who proclaimed 25 centuries ago, ‚Let food be thy medicine and medicine be thy food‘. They estimated that one third of all cancer cases could be prevented by a healthier diet; statements which are widely accepted in the scientific literature. This book covers the current state-of-the art knowledge on the impact of nutrition and diet with nutrigenetics, nutritional epigenomics, nutritional transcriptomics, proteomics, and metabolomics approach in cancer prevention and therapy.
Inhaltsverzeichnis
1.Aberrant signaling pathways in cancer: Modulation by the dietary flavonoid, quercetin.- 2. “Micronutrient and Cancer: Add Spice to Your Life”.- 3. Chemoprevention of prostate cancer with cruciferous vegetables: role of epigenetics.- 4. Molecular insight and preclinical perspective of thymoquinone as chemopreventive agent and therapeutic adjunct in cancer.- 5. Dietary biofactors in the management of cancer: Reality or Myth?.- 6. Nutritional Compounds as Chemopreventive Agents by Proteasome Inhibition. -7. STAT Signaling in Cancer Prevention.- 8. gd T cells, tea and cancer.- 9. Phytochemical Intakes with a Mediterranean Diet: Levels Achievable with an Exchange List Diet and Potential Biomarkers in Blood.- 10. Plant polyphenols and their role in cancer prevention and chemotherapy.- 11. Role of Food Micro-molecules in the Prevention of Cancer.- 12. The protective role of zinc in cancer: A potential chemopreventive agent.- 13. Diet-induced Epigenetic Changes and Cancer Prevention: A Mantra for Healthy Living.- 14. Western Diet-Induced Pancreatic Cancer.- 15. Intracellular signaling network as a prime chemotherapy target of green tea catechin, (–)-epigallocatechin-3-gallate.- 16. Role of Dietary Antioxidants in Cancer.- 17. Curcumin: Structure, Biology and Clinical Applications.- 18. Obesity, cancer and psychopathology: can vegetarian diet be of help?.- 19. Dietary Phytochemicals as Epigenetic Modulators in Cancer.- 20. “Modulation of the Nrf2 signaling pathway by chemopreventive dietary phytoconstituents”.- 21. Role of fish oil from gene expression to pharmacological effects in cancer prevention.- 22. “Antioxidant supplements: An evidence-based approach to health benefits and risks‘.- 23. Natural Antioxidants and Their Role in Cancer Prevention.- 24. Dietary and Non-dietary Phytochemicals in Cancer Control.
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