"Advanced Physical Chemistry" is a textbook for students majored in chemistry and chemical engineering. It contains comprehensively various topics in depth with a focus on basic principles, new trends and applications. The whole book is composed of five parts, Equilibrium, Rate, Structure, Statistics, and Extension, covering the macroscopic level, the transition level from microscopic to macroscopic and the microscopic level. Those characteristic properties obtained by the experimental, the semi-empirical, and the theoretical methods that should be incorporated with the basic principles to solve the practical problems are paid more attention. The Framework of the whole book and of each chapter is stressed which will be helpful for readers to manage the scientific essentials. A Brief History is presented at the end of each chapter to widen the horizon. General Problems and Numerical Problems are provided to enhance the learning. The book can also be used for corresponding researchers and engineers as a necessary reference.