Author: F. Melchers

…

…

…

…

…

…

The study of the genetic regulation of immune response to natural multidetermi- nant immunogens was undertaken by the method of bidirectional selective breed- ing of High or Low antibody responder …

Sponsored by the National Cancer Institute …

…

Several discoveries are noteworthy for allowing us to probe the recesses of the virus- infected cell and to search for cryptic viral genomes which might provide clues in our studies of cancer …

…

…

…

For more than ten years cell fusion techniques have been applied in studies on various lymphocyte functions. Ig expression was first studied in hybrids obtained by fusing myeloma cells with …

Binding of various ligands (hormones, neurotransmitters, immunological stimuli) to membrane receptors induces the following changes: 1. Receptor redistribution (clustering, "capping") 2. …

…

and how the known vertebrate homologues of these genes are expressed normally in differentiation and proliferation pathways as well as abnormal- ly in well-defined lymphomagenic and other oncogenic …

…

…

…

…

The cells of the immune system generate a large variety of binding sites which differ in their binding specificities and can therefore react specifically with a large variety of ligands. These …