Table des matières
The Genetics of Alzheimer’s Disease.- APP Biology, Processing and Function.- The Biology of the Presenilin Complexes.- ?-secretase: Physiological Role and Target Validation.- Cognitive Impairment in Transgenic A? and Tau Models of Alzheimer’s Disease.- Cholesterol and ?-Amyloid.- A? Structure and Aggregation.- Signaling Mechanisms that Mediate A? Induced Neuronal Dysfunction.- Beta Amyloid and Excitatory Synapses.- A? Degradation.- Role of A ? Transport and Clearance in the Pathogenesis and Treatment of Alzheimer’s Disease.- Tau Gene Mutations in FTDP-17 Syndromes.- Animal Models of Tauopathy.- Tau and Axonal Transport.- Growth Factors in Alzheimer’s Disease.
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Langue Anglais ● Format PDF ● Pages 286 ● ISBN 9780387351353 ● Taille du fichier 3.5 MB ● Éditeur Sangram S. Sisodia & Rudolph E. Tanzi ● Maison d’édition Springer US ● Lieu NY ● Pays US ● Publié 2007 ● Téléchargeable 24 mois ● Devise EUR ● ID 2144943 ● Protection contre la copie DRM sociale