The extracellular matrix (ECM) supports cells and regulates various cellular functions in our body. The native ECM promises to provide an excellent scaffold for regenerative medicine. In order to use the ECM as a scaffold in medicine, its cellular fractions need to be removed while retaining its structural and compositional properties. This process is called decellularization, and the resulting product is known as the decellularized extracellular matrix (d ECM). This book focuses on the sources of d ECM and its preparation, characterization techniques, fabrication, and applications in regenerative medicine and biological studies. Using this book, the reader will gain a good foundation in the field of ECM decellularization complemented with a broad overview of d ECM characterization, ranging from structural observation and compositional assessment to immune responses against d ECM and applications, ranging from microfabrication and 3D-printing to the application of tissue-derived d ECM in vascular grafts and corneal tissue engineering etc. The book closes with a section dedicated to cultured cell d ECM, a complementary technique of tissue-derived d ECM preparation, for application in tissue engineering and regenerative medicine, addressing its use in stem cell differentiation and how it can help in the study of the tumor microenvironment as well as in clinical trials of peripheral nerve regeneration.
Tetsuji Yamaoka & Takashi Hoshiba
Decellularized Extracellular Matrix [EPUB ebook]
Characterization, Fabrication and Applications
Decellularized Extracellular Matrix [EPUB ebook]
Characterization, Fabrication and Applications
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Langue Anglais ● Format EPUB ● Pages 352 ● ISBN 9781839161261 ● Taille du fichier 14.5 MB ● Éditeur Tetsuji Yamaoka & Takashi Hoshiba ● Maison d’édition Royal Society of Chemistry ● Publié 2019 ● Édition 1 ● Téléchargeable 24 mois ● Devise EUR ● ID 7307580 ● Protection contre la copie Adobe DRM
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