The extracellular matrix (ECM) supports cells and regulates various cellular functions in our body. The native ECM promises to provide an excellent scaffold for regenerative medicine. In order to use the ECM as a scaffold in medicine, its cellular fractions need to be removed while retaining its structural and compositional properties. This process is called decellularization, and the resulting product is known as the decellularized extracellular matrix (d ECM). This book focuses on the sources of d ECM and its preparation, characterization techniques, fabrication, and applications in regenerative medicine and biological studies. Using this book, the reader will gain a good foundation in the field of ECM decellularization complemented with a broad overview of d ECM characterization, ranging from structural observation and compositional assessment to immune responses against d ECM and applications, ranging from microfabrication and 3D-printing to the application of tissue-derived d ECM in vascular grafts and corneal tissue engineering etc. The book closes with a section dedicated to cultured cell d ECM, a complementary technique of tissue-derived d ECM preparation, for application in tissue engineering and regenerative medicine, addressing its use in stem cell differentiation and how it can help in the study of the tumor microenvironment as well as in clinical trials of peripheral nerve regeneration.
Innehållsförteckning
Extracellular Matrix Scaffolds for Tissue Engineering and Biological Research; Preparation Methods for Tissue/Organ-derived d ECMs – Effects on Cell Removal and ECM Changes; Preparation of Cultured Cell-derived Decellularized Matrix (d ECM) – Factors Influencing d ECM Formation and Its Ability; Bared Basement Membrane Substrata: Design, Cellular Assembly, Decellularization and Application to Tissue Regeneration and Stem Cell Differentiation; A Novel Treatment for Giant Congenital Melanocytic Nevi Combining Inactivated Nevus Tissue by Pressurization and Cultured Epidermal Autograft; Immune Responses to Decellularized Matrices; Decellularized Extracellular Matrix Hydrogels: Fabrication, Properties, Characterization, and Current Applications; Decellularized Extracellular Matrix as Bioink for 3D-Bioprinting; Mechanical Property Tunable d ECM and Their Regenerative Applications; Use of Small Intestinal Submucosa d ECM in Tissue Engineering and Regenerative Medicine; Small-diameter Acellular Vascular Grafts: From Basic Research to Clinical Application; Decellularized Matrix for Corneal Tissue Engineering: Recent Advances in Development and Clinical Potential; Engineering an Endocrine Neo-Pancreas; Decellularized Cell-Secreted Matrices: Novel Materials for Superior Stem Cell Expansion and Tissue Engineering; Decellularized Extracellular Matrix for the Regulation of Stem Cell Differentiation; Fibroblastic Cell-Derived Extracellular Matrices: A Cell Culturing System to Model Key Aspects of the Tumor Microenvironment; Extracellular Matrix in Peripheral Nerve Regeneration
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