TGF-beta, originally identified as a transforming growth factor with similar properties, is now known to exist as a family of factors with similar properties. These factors promote cell proliferation in some tissue types or conditions and induce cell differentiation in others. Features the latest information on the TGF-beta family and its receptors. Describes correlations between TGF-beta and certain cancers, including glioblastomas. Also contains reports of preliminary investigations of clinical applications for TGF-beta in many diseases, including leukemia and its use to accelerate wound healing.
Table of Content
Partial table of contents:
Multiple Forms of TGF-beta: Distinct Promoters and
Differential Expression (A. Roberts, et al.).
Mechanisms in TGF-beta Action (J. Massagué, et
al.).
Regulation of Epithelial Proliferation by TGF-beta (H. Moses,
et al.).
Latent Forms of TGF-beta: Molecular Structure and Mechanisms
of Action (K. Miyazono & C. Heldin).
TGF-beta: A Possible Autocrine Immune Regulator (C. Lucas,
et al.).
TGF-beta and Wound Healing (E. Amento & L. Beck).
The Effects of TGF-beta on Bone (G. Mundy).
Effects of TGF-betas in the Liver: Cell Proliferation and
Fibrogenesis (N. Fausto, et al.).
Role of TGF-beta1 in Experimental Glomerulonephritis (W.
Border, et al.).
In Vivo and in Vitro Effects of TGF-beta1 on
Normal and Neoplastic Hemopoiesis (F. Ruscetti, et al.).
Expression of TGF-beta2 in Human Glioblastoma: A Role in
Resistance to Immune Rejection?
(A. Fontana, et al.).
Index of Contributors.
Subject Index.
About the author
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.
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