TGF-beta, originally identified as a transforming growth factor with similar properties, is now known to exist as a family of factors with similar properties. These factors promote cell proliferation in some tissue types or conditions and induce cell differentiation in others. Features the latest information on the TGF-beta family and its receptors. Describes correlations between TGF-beta and certain cancers, including glioblastomas. Also contains reports of preliminary investigations of clinical applications for TGF-beta in many diseases, including leukemia and its use to accelerate wound healing.
Tabela de Conteúdo
Partial table of contents:
Multiple Forms of TGF-beta: Distinct Promoters and
Differential Expression (A. Roberts, et al.).
Mechanisms in TGF-beta Action (J. Massagué, et
al.).
Regulation of Epithelial Proliferation by TGF-beta (H. Moses,
et al.).
Latent Forms of TGF-beta: Molecular Structure and Mechanisms
of Action (K. Miyazono & C. Heldin).
TGF-beta: A Possible Autocrine Immune Regulator (C. Lucas,
et al.).
TGF-beta and Wound Healing (E. Amento & L. Beck).
The Effects of TGF-beta on Bone (G. Mundy).
Effects of TGF-betas in the Liver: Cell Proliferation and
Fibrogenesis (N. Fausto, et al.).
Role of TGF-beta1 in Experimental Glomerulonephritis (W.
Border, et al.).
In Vivo and in Vitro Effects of TGF-beta1 on
Normal and Neoplastic Hemopoiesis (F. Ruscetti, et al.).
Expression of TGF-beta2 in Human Glioblastoma: A Role in
Resistance to Immune Rejection?
(A. Fontana, et al.).
Index of Contributors.
Subject Index.
Sobre o autor
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.
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