Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both a...
विषयसूची
An Introduction to Wnt Signaling.- Regulation of Wnt Secretion and Distribution.- Wnt Signaling in Stem Cells.- Crosstalk of the Wnt Signaling Pathway.- Dysregulatio...
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भाषा अंग्रेज़ी ● स्वरूप PDF ● पेज 240 ● ISBN 9781441980236 ● फाइल का आकार 5.5 MB ● आयु 02-99 वर्षों ● संपादक Kathleen H. Goss & Michael Kahn ● प्रकाशक Springer New York ● शहर NY ● देश US ● प्रकाशित 2011 ● डाउनलोड करने योग्य 24 महीने ● मुद्रा EUR ● आईडी 2150554 ● कॉपी सुरक्षा सामाजिक DRM