Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathway.
Tabella dei contenuti
An Introduction to Wnt Signaling.- Regulation of Wnt Secretion and Distribution.- Wnt Signaling in Stem Cells.- Crosstalk of the Wnt Signaling Pathway.- Dysregulation of the WNT Pathway in Solid Tumors.- WNT/b-catenin Signaling in Leukemia.- Use of Genetically-engineered Mouse Models in Identification and Validation of Therapeutic Targets for Colon Cancer.- Targeting Wnt Signalling in Cancer.- Inhibiting the Wnt Signaling Pathway with Small Molecules.- Targeting of Wnt Signaling Inside the Nucleus.-
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