Extracellular and biofluids vesicles (EVs) are highly specialised yet ubiquitous nanoscale messengers secreted by cells. With the development of stem cell engineering, EVs promise to deliver next generation tools in regenerative medicine and tissue engineering, as well as in diagnostics. A vibrant and promising field, this book provides the first resource to the field.
Covering basic cell biology, including EV production and intracellular communication, this book will provide material scientists and engineers with a foundation to the necessary biology. The reader will then learn about the isolation of extracellular vesicles their physicochemical characterisation and therapeutic application of EVs in regenerative medicine as well as their potential as biomarkers in medical diagnostic. This book will also discuss the regulatory landscape of EVs.
Bridging cell biology, biomaterials, biophysics and biomedical engineering the content of this book is written with a broad interdisciplinary audience in mind. Researchers, new and established will find this a must-have on their shelf.
Daftar Isi
Therapeutic Potential of Mesenchymal Stromal Cell-derived Small Extracellular Vesicles; Separation and Purification of Extracellular and Bio-fluid Vesicles – State of the Art: Past, Present, and Future of Extracellular Vesicle Separation and Purification; Physicochemical Characterisation of Extracellular Vesicles; Biological Characterization of Extracellular Vesicles – Methodologies to Characterize Molecular Composition of Extracellular Vesicles – Advances Towards Single Vesicle Characterization; Extracellular Vesicles in Bone Tissue Engineering; Mesenchymal Stromal Cell (MSC)-derived Small Extracellular Vesicles as Next-generation Therapeutics for Cartilage Regeneration; The Role of Extracellular Vesicles in the Neuronal System: Application of Extracellular Vesicles in Alzheimer’s Disease, Parkinson’s Disease, Multiple Sclerosis, and Dementia; The Role of Extracellular Vesicles in Aging of the Human Placenta; Extracellular Vesicles in Lung Diseases; Immunomodulatory Function of Extracellular Vesicles in Cancer and Tissue Repair/Regeneration; Diagnostic Applications of Extracellular and Bio-fluid Vesicles; Standardization and Commercialization of Extracellular Vesicles
Tentang Penulis
Dr Chrzanowski has over 12 years in the area of biomaterials with over 50 papers, 2 books (monographs). He graduated from the Silesian University of Technology, where he also obtained my Ph D. After receiving a prestigious fellowship I moved to University College London to work in Biomaterials and Tissue Engineering laboratory and develop novel osteogenic materials. In 2008 he moved to the University of Glasgow where I joined large EU consortium providing his expertise in the synthesis of materials for orthopaedic applications. In 2010 he moved to the University of Sydney where I established my laboratory working currently with six Ph D students.
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