After the discovery of endogenous NO formation in the late ’80s and the 1998 Nobel Prize in Physiology or Medicine, many researchers and physicians again became interested in the NO/s GC interaction and c GMP-dependent signaling. This book is an enthusiastic celebration of cyclic guanosine monophosphate (c GMP) and amply illustrates the importance of this field of science to patients and the way in which the field has evolved. It is exclusively devoted to this exciting and important signaling molecule, addressing all recent advances in understanding guanylate cyclase regulation, NO/s GC interactions, c GMP effector mechanisms and their pathophysiological and pharmacological implications. Particular attention will also be given to clinical applications of the novel c GMP-elevating drugs which are on the horizon, thus spanning the continuum from basic science to clinic.
Daftar Isi
Basic Generators and Effectors.- A Short History of c GMP, Guanylyl Cyclases, and c GMP-Dependent Protein Kinases.- Biochemistry of Soluble Guanylate Cyclase.- Genetic Mouse Models of the NO Receptor ‘Soluble’ Guanylyl Cyclases.- Function and Dysfunction of Mammalian Membrane Guanylyl Cyclase Receptors: Lessons from Genetic Mouse Models and Implications for Human Diseases.- Phosphodiesterases in the Central Nervous System.- Structural and Biochemical Aspects of Tandem GAF Domains.- Cyclic Nucleotide-Gated Channels.- c GMP Regulated Protein Kinases (c GK).- c GK Substrates.- Biochemical Detection of c GMP From Past to Present: An Overview.- Novel Techniques for Real-Time Monitoring of c GMP in Living Cells.- Pharmacology of c GMP.- NO and s GC-Stimulating NO Donors.- NO-Independent, Haem-Dependent Soluble Guanylate Cyclase Stimulators.- NO- and Haem-Independent Soluble Guanylate Cyclase Activators.- Natriuretic Peptides: Their Structures, Receptors, Physiologic Functions and Therapeutic Applications.- Cyclic GMP-Hydrolyzing Phosphodiesterases.- c GMP-Dependent Protein Kinase Modulators.- c GMP-Dependent Protein Kinase as a Modifier of Behaviour.- Clinical Applications.- c GMP in the Vasculature.- Modulating c GMP to Treat Lung Diseases.- Modulation of c GMP in Heart Failure: A New Therapeutic Paradigm.- Erectile Dysfunction and Lower Urinary Tract.- c GMP and c GMP-Dependent Protein Kinase in Platelets and Blood Cells.- c GMP Signalling in the Mammalian Brain: Role in Synaptic Plasticity and Behaviour.
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