Interplay between Metal Ions and Nucleic Acids provides in an authoritative and timely manner in 12 stimulating chapters, written by 24 internationally recognized experts from 8 nations, and supported by nearly 1500 references, about 20 tables, and 125 illustrations, many in color, a most up-to-date view on metal ion-nucleic acid interactions; the characterization of which is covered in solution and in the solid state. The volume concentrates on modern developments encompassing topics in the wide range from G-quadruplexes via DNAzymes, catalysis at the DNA scaffold, and metal-mediated base pairs to peptide nucleic acids (PNAs) being thus of relevance, e.g., for chemistry and nanotechnology but also for molecular biology and (genetic) diagnostics.
Tabella dei contenuti
1. Characterization of Metal Ion-Nucleic Acid Interactions in Solution. – 2. Nucleic Acid-Metal Ion Interactions in the Solid State. – 3. Metal Ion-Promoted Conformational Changes of Oligonucleotides. – 4. G-Quadruplexes and Metal Ions. – 5. Metal Ion-Mediated DNA-Protein Interactions. – 6. Spectroscopic Investigations of Lanthanide Ion Binding to Nucleic Acids. – 7. Oxidative DNA Damage Mediated by Transition Metal Ions and Their Complexes. – 8. Metal Ion-Dependent DNAzymes and Their Applications as Biosensors. – 9. Enantioselective Catalysis at the DNA Scaffold. – 10. Alternative DNA Base Pairing through Metal Coordination. – 11. Metal-Mediated Base Pairs in Nucleic Acids with Purine- and Pyrimidine-Derived Nucleosides. – 12. Metal Complex Derivatives of Peptide Nucleic Acids.
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