This book constitutes the proceedings of the 10th Enterprise Engineering Working Conference, EEWC 2020, which was planned to take place in Bozen-Bolzano, Italy, and had to change to an online event due to the COVID 19 pandemic. The online event took place on September 28, 2020, October 19, 2020, and November 9-10, 2020.EEWC aims at addressing the challenges that modern and complex enterprises are facing in a rapidly changing world. The participants of the working conference share a belief that dealing with these challenges requires rigorous and scientific solutions, focusing on the design and engineering of enterprises. The goal of EEWC is to stimulate interaction between the different stakeholders, scientists as well as practitioners, interested in making Enterprise Engineering a reality.The 8 full papers and 2 short papers presented in this volume were carefully reviewed and selected from 23 submissions. The volume also contains 3 keynote papers in full paper length. Thepapers were organized in topical sections as follows: formal approaches and modeling; the DEMO modeling language; and enterprise engineering practice.