Solid-phase synthesis of carbohydrates presents unique challenges
to synthetic chemists and currently represents one of the hottest
areas of research in bioorganic chemistry. Solid Support
Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries
addresses the exciting expectation that solid-phase assembly of
oligosaccharides will have a fundamental impact on the field of
glycobiology. This publication details the methodologies currently
investigated for the attach...
Solid-phase synthesis of carbohydrates presents unique challenges
to synthetic chemists and currently represents one of the hottest
areas of research in bioorganic chemistry. Solid Support
Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries
addresses the exciting expectation that solid-phase assembly of
oligosaccharides will have a fundamental impact on the field of
glycobiology. This publication details the methodologies currently
investigated for the attachment of carbohydrates to beads,
synthesis including coupling strategies, and removal of the product
from beads.
With chapters written by eminent contributing authors, the material
explores different synthetic strategies, glycosylation protocols,
the use of solid supports versus soluble polymeric supports, and
'on-resin’ analytical methods. Tremendous progress in the field has
set the stage for Solid Support Oligosaccharide Synthesis and
Combinatorial Carbohydrate Libraries to provide a wealth of
information on such topics as:
* Specific oligosaccharide structures used in signal transduction
processes
* Preparation and screening of glycopeptide libraries
* Solid-phase carbohydrate synthesis