Peter H. Seeberger 
Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries [PDF ebook] 

Solid-phase synthesis of carbohydrates presents unique challenges
to synthetic chemists and currently represents one of the hottest
areas of research in bioorganic chemistry. Solid Support
Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries
addresses the exciting expectation that solid-phase assembly of
oligosaccharides will have a fundamental impact on the field of
glycobiology. This publication details the methodologies currently
investigated for the attachment of carbohydrates to beads,
synthesis including coupling strategies, and removal of the product
from beads.

With chapters written by eminent contributing authors, the material
explores different synthetic strategies, glycosylation protocols,
the use of solid supports versus soluble polymeric supports, and
‘on-resin’ analytical methods. Tremendous progress in the field has
set the stage for Solid Support Oligosaccharide Synthesis and
Combinatorial Carbohydrate Libraries to provide a wealth of
information on such topics as:

* Specific oligosaccharide structures used in signal transduction
processes

* Preparation and screening of glycopeptide libraries

* Solid-phase carbohydrate synthesis

Зміст

Preface.

Contributors.

Solid-Phase Carbohydrate Synthesis: The Early Work (W.-C. Haase
& P. Seeberger).

The Glycal Assembly Method on Solid Supports: Synthesis of
Oligosaccharides and Glycoconjugates (P. Cirillo & S.
Danishefsky).

The Sulfoxide Glycosylation Method and its Application to
Solid-Phase Oligosaccharide Synthesis and the Generation of
Combinatorial Libraries (C. Taylor).

The Use of O-Glycosyl Trichloroacetimidates for the
Polymer-Supported Synthesis of Oligosaccharides (L. Knerr & R.
Schmidt).

Synthesis of Oligosaccharides on Solid Support Using Thioglycosides
and Pentenyl Glycosides (V. Wittmann).

Solid-Phase Oligosaccharide Synthesis Using Glycosyl Phosphates
(W.-C. Haase, et al.).

Stereoselective -Mannosylation on Polymer Support (Y. Ito & H.
Ando).

Tools for ‘On-Bead’ Monitoring and Analysis in Solid-Phase
Oligosaccharide Synthesis (W.-C. Haase, et al.).

Polyethyleneglycol -Monomethylether (MPEG)-Supported Solution-Phase
Synthesis of Oligosaccharides (J. Krepinsky & S.
Douglas).

Two-Direction Glycosylations for the Preparation of Libraries of
Oligosaccharides (G.-J. Boons & T. Zhu).

Carbohydrate Libraries in Solution Using Thioglycosides: From
Multistep Synthesis to Programmable, One-Pot Synthesis (E. Simanek
& C.-H. Wong).

Carbohydrate Libraries by the Random Glycosylation Approach (O.
Kanie & O. Hindsgaul).

Solid-Phase Synthesis of Biologically Important Glycopeptides (N.
Bézay & H. Kunz).

Preparation and Screening of Glycopeptide Libraries (P. St.
Hilaire, et al.).

Index.

Про автора

PETER H. SEEBERGER is Firmenich Assistant Professor of Chemistry at the Massachusetts Institute of Technology in Cambridge, Massachusetts.