This volume constitutes the refereed proceedings of the 25th European Conference on Systems, Software and Services Process Improvement, Euro SPI conference, held in Bilbao, Spain, in September 2018.The 56 revised full papers presented were carefully reviewed and selected from 95 submissions. They are organized in topical sections on SPI context and agility, SPI and safety testing, SPI and management issues, SPI and assessment, SPI and safety critical, gamify SPI, SPI in industry 4.0, best practices in implementing traceability, good and bad practices in improvement, safety and security, experiences with agile and lean, standards and assessment models, team skills and diversity strategies, SPI in medical device industry, empowering the future infrastructure.