Research on the roles played by hostility and anger in the etiology and course of coronary heart disease (CHD) has mushroomed. Moreover, there has been considerable progress in the knowledge of neurohormonal correlates of anger and hostility that could conceivably play a role in the pathogenesis of CHD. The editors of this volume believe that this is the appropriate time in the history of coronary-prone behavior research to take stock – to identify the basic questions that need further elucidation, and to provide future direction. Although there is a surprising consensus among the contributors about the nature of the critical issues, they each offer a somewhat different perspective. This book will provide a variety of perspectives on what is known and what still needs to be known – a useful source for promising research hypotheses.