Despite ongoing efforts to prohibit the production, storage and use of chemical warfare agents recent world events highlight the enduring threat to the population from these agents. Research efforts in various countries have resulted in novel insights into chemical warfare toxicology that has enabled the development of new approaches for the diagnosis and treatment of chemical warfare poisoning. This book provides an up-to-date treatise on the ongoing research into the toxicology of chemical warfare agents, the diagnosis and verification of exposure, and the pre- and post-exposure treatment of poisoning. Focussing on the fundamentals of the toxicology of nerve agents and vesicants, this book will give the reader a comprehensive overview of the many different aspects of chemical warfare agent toxicology. The text will appeal to toxicologists, biochemists and weapons specialists working in industry and academia, and anyone with an interest in chemical warfare toxicology or exposure.
Cuprins
Development, historical use and properties of chemical warfare agents; Toxicology of Vesicants; Toxicology of organophosphorus nerve agents; Toxicology and treatment of phosgene induced lung injury; Human exposures to sulfur mustard; Long-term effects of the chemical warfare agent sulfur mustard; Toxicokinetics of sulfur mustard; Modelling organophosphorus chemical warfare nerve agents: A physiologically based pharmacokinetic-pharmacodynamic (PBPK-PD) model of VX; Allometric modelling of mammalian cyanogen chloride inhalation lethality;
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