This revised and updated second edition of Handbook of Hematologic Malignancies continues to be an essential and ‘go-to’ resource for the busy hematologist, hematologic oncologist, hematopathologist, oncology advanced practice provider, oncology nurse, and trainee. Concisely organized, each chapter provides the most current, need-to-know points of diagnosis, prognosis, therapeutic management, and clinical trial opportunities for each hematological malignancy. Chapters are complete with richly illustrated figures to highlight the hematopathologic characteristics of diseases in addition to helpful tables on differential diagnosis, prognostic scoring systems, molecular profiles, and therapeutic options. A new case-based chapter concludes the handbook with clinical cases designed to test a clinician’s knowledge of pathologic diagnosis and clinical presentation of diseases covered in the book. With over twenty new FDA-approved indications since publication of the first edition, including breakthroughs with CAR-T therapy, and other evidence-based treatment options for patients with hematologic disease, this book serves as quick reference to practice changing information on challenging diagnostic dilemmas, frontline and refractory treatment scenarios, and more.
The subspecialty field of hematologic oncology is ever-changing and expanding with available treatment options and this second edition keeps the busy clinician abreast of recent findings and their impact on evidence-based treatment and management. Written by experienced clinicians at the world-renowned Moffitt Cancer Center in Tampa, Florida, as well as contributions from leading academicians, hematologists, and oncologists throughout the country, this unique handbook is packed with authoritative knowledge and clinical insight into all known hematologic cancers.
- Includes seven new chapters covering CAR-T and novel therapeutic options including CD19 CAR-T therapy, novel cellular therapies, cytokine release syndrome, cancer associated thrombosis, and more
- Comprises compact and updated disease-site chapters describing new standards of care and management considerations in bullet point format with key references
- Highlights important diagnostic tools that assist with conducting key differential diagnoses and unveiling answers to diagnostic dilemmas
- Provides updates of potential practice-changing clinical trials and paradigm shifting treatment considerations in each disease-based chapter
Key Features:
Cuprins
Contributors
Preface
PART I: INTRODUCTION AND OVERVIEW
Chapter 1. Normal Hematopoiesis and Diagnosis Algorithms for Cytopenias and Cytoses by Onyee Chan and Ling Zhang
Chapter 2. Familial/Inherited Mutations and Risks of Hematologic Malignancies by Sophia C. Korotev, Lucy A. Godley, and Amy M. Trottier
Chapter 3. Hematopathology Diagnostic Techniques and Assays by Johnny Nguyen, Rohit Sharma, and Ling Zhang
Chapter 4. Minimal Residual Disease Assays by Pukhraz Basra and Silvia Tse Bunting
PART II: MYELOPROLIFERATIVE NEOPLASMS
Chapter 5. Polycythemia Vera by Misty Dawn Shields and Kenneth S. Zuckerman
Chapter 6. Essential Thrombocythemia by Nikesh N. Shah and Kenneth S. Zuckerman
Chapter 7. Primary Myelofibrosis by Carmelo J. Blanquicett and Andrew Kuykendall
Chapter 8. Chronic Myelogenous Leukemia by Chetasi Talati, Dasom Lee, and Javier Pinilla-Ibarz
Chapter 9. Chronic Neutrophilic Leukemia by Yenny Alejandra Morena Vanegas, Arun Kadamkulam Syriac, and Utkarsh Acharya
Chapter 10. Systemic Mastocytosis by Andrew Kuykendall and Kristen Gonter-Aubin
Chapter 11. PDGFRA/PDGFRB/FGFR1 Myeloid Neoplasms by Joseph Clara and Eric Padron
PART III: MYELODYSPLASTIC AND BONE MARROW FAILURE SYNDROMES
Chapter 12. Myelodysplastic Syndromes by Anthony M. Hunter, David A. Sallman, and Rami Komrokji
Chapter 13. Aplastic Anemia by Jae Chung and Rami Komrokji
Chapter 14. Paroxysmal Nocturnal Hemoglobinuria by Hilda Ding
PART IV: MYELODYSPLASTIC/MYELOPROLIFERATIVE NEOPLASMS
Chapter 15. Myelodysplastic/Myeloproliferative Overlap Syndromes by Virginia O. Volpe and Eric Padron
Chapter 16. Chronic Myelomonocytic Leukemia by Alexandra Gomez-Arteaga and Justin M. Watts
PART V: ACUTE MYELOID LEUKEMIA AND RELATED SYNDROMES
Chapter 17. Acute Myeloid Leukemia by David M. Swoboda and Kendra Sweet
Chapter 18. Secondary AML and AML With Myelodysplasia-Related Changes by Seongseok Yun, David A. Sallman, and Jeffrey E. Lancet
Chapter 19. Acute Promyelocytic Leukemia by Virginia O. Volpe and Jeffrey E. Lancet
Chapter 20. Blastic Plasmacytoid Dendritic Cell Neoplasm by Justin Taylor and Andrew A. Lane
PART VI: ACUTE LYMPHOID LEUKEMIA
Chapter 21. B-Lymphoblastic Leukemia/Lymphoma by Fernando Vargas and Bijal Shah
Chapter 22. BCR-ABL1+ B-Lymphoblastic Leukemia by Yehuda Deutsch and Bijal Shah
Chapter 23. T-Lymphoblastic Lymphoma/Leukemia by Muhammad Sardar, Ravitharan Krishnadasan, and Keri Maher
PART VII: ACUTE LEUKEMIA OF AMBIGUOUS LINEAGE
Chapter 24. Acute Leukemia of Ambiguous Lineage by Muhammad Sardar, Ravitharan Krishnadasan, and Keri Maher
PART VIII: MATURE T- AND NK-CELL LEUKEMIA
Chapter 25. T-Cell Prolymphocytic Leukemia by Abhijeet Kumar and Pei Zhang
Chapter 26. T-Cell Large Granular Lymphocytic Leukemia by Ning Dong, Magali Van den Bergh, and Lubomir Sokol
Chapter 27. Aggressive Natural Killer Cell Leukemia by Emilie Wang, Mintallah Haider, and Lubomir Sokol
PART IX: PLASMA CELL DISORDERS
Chapter 28. Monoclonal Gammopathy of Unknown Significance, Smoldering Myeloma, and Plasmacytomas by Hannah Asghari and Brandon Blue
Chapter 29. Multiple Myeloma by Shonali Midha, Patrick Griffin, and Rachid Baz
Chapter 30. Waldenström’s Macroglobulinemia by Ariel Grajales-Cruz and Rachid Baz
Chapter 31. Immunoglobulin Light Chain Amyloidosis by Taxiarchis Kourelis and Morie Gertz
PART X: HODGKIN LYMPHOMA
Chapter 32. Hodgkin Lymphoma by Anju Nair
PART XI: NON-HODGKIN LYMPHOMA
Chapter 33. Non-Hodgkin Lymphoma Classification and Diagnostic Evaluation by Johnny Nguyen, Haipeng Shao, and Ling Zhang
PART XII: MATURE B-CELL LYMPHOMA
VERY AGGRESSIVE
Chapter 34. Burkitt Lymphoma by Anju Nair
AGGRESSIVE
Chapter 35. Diffuse Large B-Cell Lymphoma by Jose D. Sandoval-Sus and Julio C. Chavez
Chapter 36. Double Hit Lymphoma by Nikhil Mukhi
Chapter 37. Mantle Cell Lymphoma by Ruchi Desai and Bijal Shah
Chapter 38. Primary Mediastinal Large B-Cell Lymphoma by Vania Phuoc and Julio C Chavez
Chapter 39. Primary Central Nervous System Lymphoma by Tony Kurian, Liliana Bustamante, Peter Forsyth, and Solmaz Sahebjam
Chapter 40. HIV-Related Lymphomas by Danny Nguyen, Nishan Tchekmedyian, and Jeremy S. Abramson
INDOLENT
Chapter 41. Follicular Lymphoma by Jori Kaplan and Celeste Bello
Chapter 42. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma by Emilie Wang, Ateefa Chaudhury, and Javier Pinilla-Ibarz
Chapter 43. Hairy Cell Leukemia by Justin Taylor and Omar Abdel-Wahab
Chapter 44. Marginal Zone Lymphoma by Nishan Tchekmedyian, Danny Nguyen, Hayder Saeed, and Celeste Bello
Chapter 45. Mucosa-Associated Lymphoid Tissue Lymphoma by Nishan Tchekmedyian, Danny Nguyen, and Hayder Saeed
PART XIII: MATURE T/NK-CELL LYMPHOMA
Chapter 46. Adult T-Cell Leukemia/Lymphoma by Nikhil Mukhi and Lubomir Sokol
Chapter 47. Anaplastic Large Cell Lymphoma, ALK Positive by Poorvi Desai, Ling Zhang, and Lubomir Sokol
Chapter 48. Extranodal Natural Killer/T-Cell Lymphoma by Joseph Clara and Lubomir Sokol
Chapter 49. Mycosis Fungoides by Vania Phuoc and Lubomir Sokol
Chapter 50. Hepatosplenic T-Cell Lymphoma by Walter Hanel and Narendranath Epperla
PART XIV: HISTIOCYTIC/DENDRITIC CELL NEOPLASMS
Chapter 51. Histiocytic Sarcoma, Langerhans Cell Histiocytosis, Erdheim-Chester Disease, and Rosai-Dorfman Disease by Sameem Abedin and Ehab Atallah
Chapter 52. Hemophagocytic Lymphohistiocytosis by Hilda Ding and Lubomir Sokol
PART XV: BONE MARROW TRANSPLANTATION
Chapter 53. Autologous Bone Marrow Transplantation by Hemant S. Murthy and Mohamed A. Kharfan-Dabaja
Chapter 54. Allogeneic Bone Marrow Transplantation by Hemant S. Murthy, Taiga Nishihori and Mohamed A. Kharfan-Dabaja
PART XVI: NEW CELLULAR IMMUNOTHERAPY
Chapter 55. CAR-T and Novel Cellular Therapeutic Options in Hematologic Malignancies by Cristian I. Rodriguez Arocho, Marco L. Davila, and David A. Sallman
Chapter 56. CD19 CAR-T Therapy by Michael D. Jain, Brigett D. Brandjes, and Fredreick L. Locke
Chapter 57. Cytokine Release Syndrome by Jennifer M. Logue, Estelle Cervantes, Christina A. Bachmeier, and Marco L. Davila
PART XVII: EMERGENCIES IN HEMATOLOGY
Chapter 58. Cancer Associated Thrombosis by Arun Kadamkulam Syriac, Karen Feghali, and Utkarsh Acharya
Chapter 59. Tumor Lysis Syndrome by Mintallah Haider and Michael Jaglal
Chapter 60. Thrombotic Microangiopathy by Jonathan R. Day, Ljiljana V. Vasovic, and Ruchika Goel
Chapter 61. Therapeutic Apheresis Indications by Ljiljana V. Vasovic, Jonathan R. Day, and Ruchika Goel
PART XVIII: NEW CLINICAL CASES IN MALIGNANT HEMATOLOGY
Chapter 62. Challenging Case Vignettes with Follow-Up Questions
Appendix: Pathology Supplement
Despre autor
Ling Zhang, MD, is a Senior Member in the Department of Hematopathology and Laboratory Medicine, and Director of the Hematopathology Fellowship Program, H. Lee Moffit Cancer Center and Research Institute at the University of South Florida Morsani College of Medicine in Tampa, Florida.
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