Presentation slides from the year 2014 in the subject Chemistry – General, grade: 1, 3, University of Cologne (Anorganische Chemie), language: English, abstract: Seminar Presentation in the subject ‘Inorganic Chemistry’ with the title ‘Organometallic Palladium Complexes with a Water-Soluble Iminophosphorane Ligand As Potential Anticancer Agents’. With the following contents:
-The problems of the currently used anticancer drugs;
– Palladium derivatives as an alternative to Platinum-based compounds;
– The first Water-Soluble Iminophosphorane Ligand;
– Preparation of Water-Soluble Ligand 1;
– Stability of Compounds in Solution;
– Cytotoxicity IC50 (μM) of Cisplatin, Ligand 1, Phosphine Oxide, TPA=O, and Metal Complexes 2-8 in Human cell lines;
– The Annexin V Binding Assay;
– Activity of Compounds 2 or 3 (50 μM) and Cisplatin against apoptosis-resistent cells;
– Chromosomal DNA and Plasmid DNA;
– Interactions of 2 and 3 with Plasmid DNA Using Electroforesis Mobility Shift Assay (EMSA);
– Interaction with Human Serum Albumin;
– Stern-Volmer plot for quenching with ligand 1 and compounds 2, 3, and 5 – 8 and cisplatin;
– Advantage over Cisplatin;
– Summery
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