Sadik Mejid 
Organometallic Palladium Complexes with a Water-Soluble Iminophosphorane Ligand As Potential Anticancer Agents [PDF ebook] 

Presentation slides from the year 2014 in the subject Chemistry — General, grade: 1, 3, University of Cologne (Anorganische Chemie), language: English, abstract: Seminar Presentation in the subject ‘Inorganic Chemistry’ with the title ‘Organometallic Palladium Complexes with a Water-Soluble Iminophosphorane Ligand As Potential Anticancer Agents’. With the following contents:
-The problems of the currently used anticancer drugs;
— Palladium derivatives as an alternative to Platinum-based compounds;
— The first Water-Soluble Iminophosphorane Ligand;
— Preparation of Water-Soluble Ligand 1;
— Stability of Compounds in Solution;
— Cytotoxicity IC50 (μM) of Cisplatin, Ligand 1, Phosphine Oxide, TPA=O, and Metal Complexes 2-8 in Human cell lines;
— The Annexin V Binding Assay;
— Activity of Compounds 2 or 3 (50 μM) and Cisplatin against apoptosis-resistent cells;
— Chromosomal DNA and Plasmid DNA;
— Interactions of 2 and 3 with Plasmid DNA Using Electroforesis Mobility Shift Assay (EMSA);
— Interaction with Human Serum Albumin;
— Stern-Volmer plot for quenching with ligand 1 and compounds 2, 3, and 5 – 8 and cisplatin;
— Advantage over Cisplatin;
— Summery