The formation of blood vessels is an essential aspect of
embryogenesis in vertebrates. It is a central feature of
numerous post-embryonic processes, including tissue and organ
growth and regeneration. It is also part of the pathology of
tumour formation and certain inflammatory conditions.
In recent years, comprehension of the molecular genetics of
blood vessel formation has progressed enormously and studies in
vertebrate model systems, especially the mouse and the zebrafish,
have identified a common set of molecules and processes that are
conserved throughout vertebrate embryogenesis while, in addition,
highlighting aspects that may differ between different animal
groups.
The discovery in the past decade of the crucial role of new
blood vessel formation for the development of cancers has generated
great interest in angiogenesis (the formation of new blood vessels
from pre-existing ones), with its major implications for potential
cancer-control strategies. In addition, there are numerous
situations where therapeutic treatments either require or would be
assisted by vasculogenesis (the de novo formation of blood
vessels). In particular, post-stroke therapies could include
treatments that stimulate neovascularization of the affected
tissues.
The development of such treatments, however, requires thoroughly
understanding the developmental properties of endothelial cells and
the basic biology of blood vessel formation.
While there are many books on angiogenesis, this unique book
focuses on exactly this basic biology and explores blood vessel
formation in connection with tissue development in a range of
animal models. It includes detailed discussions of relevant cell
biology, genetics and embryogenesis of blood vessel formation and
presents insights into the cross-talk between developing blood
vessels and other tissues.
With contributions from vascular biologists, cell biologists and
developmental biologists, a comprehensive and highly
interdisciplinary volume is the outcome.
Содержание
Christer Betsholtz Chair’s introduction 1
Maria Grazia Lampugnani and Elisabetta Dejana The control of endothelial cell functions by adherens junctions 4
Discussion 13
Maike Schmidt, Ann De Mazière, Tanya Smyczek, Alane Gray, Leon Parker, Ellen Filvaroff, Dorothy French, Suzanne van Dijk, Judith Klumperman and Weilan Ye The role of Egfl 7 in vascular morphogenesis 18
Discussion 28
Max Levin, Andrew J. Ewald, Martin Mc Mahon, Zena Werb and Keith Mostov A model of intussusceptive angiogenesis 37
Discussion 42
Tomás Kucera, Jan Eglinger, Boris Strilic and Eckhard Lammert
Vascular lumen formation from a cell biological perspective 46
Discussion 56
Christopher J. Drake, Paul A. Fleming and W. Scott Argraves
The genetics of vasculogenesis 61
Discussion 71
Steven Suchting, Catarina Freitas, Ferdinand le Noble, Rui Benedito, Christiane Bréant, Antonio Duarte and Anne Eichmann Negative regulators of vessel patterning 77
Discussion 80
Taija Mäkinen and Kari Alitalo Lymphangiogenesis in development and disease 87
Discussion 98
Irene Noguera-Troise, Christopher Daly, Nicholas J. Papadopoulos, Sandra Coetzee, Pat Boland, Nicholas W. Gale, Hsin Chieh Lin, George D. Yancopoulos and Gavin Thurston Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis 106
Discussion 121
Georg Breier, Alexander H. Licht, Anke Nicolaus, Anne Klotzsche, Ben Wielockx and Zuzana Kirsnerova HIF in vascular development and tumour angiogenesis 126
Discussion 133
Karina Yaniv, Sumio Isogai, Daniel Castranova, Louis Dye, Jiro Hitomi and Brant M. Weinstein Imaging the developing lymphatic system using the zebrafish 139
Discussion 148
Frances High and Jonathan A. Epstein Signalling pathways regulating cardiac neural crest migration and differentiation 152
Discussion 161
Ralf H. Adams Investigation of the angiogenic programme with tissue-specific and inducible genetic approaches in mice 165
Discussion 171
Gary K. Owens Molecular control of vascular smooth muscle cell differentiation and phenotypic plasticity 174
Discussion 191
Andrea Lundkvist, Sunyoung Lee, Luisa Iruela-Arispe, Christer Betsholtz and Holger Gerhardt Growth factor gradients in vascular patterning 194
Discussion 201
Deborah A. Freedman, Yasushige Kashima and Kenneth S. Zaret
Endothelial cell promotion of early liver and pancreas development 207
Discussion 216
Jörg Wilting, Kerstin Buttler, Jochen Rössler, Susanne Norgall, Lothar Schweigerer, Herbert A. Weich and Maria Papoutsi
Embryonic development and malformation of lymphatic vessels 220
Discussion 227
Joaquim Miguel Vieira, Quenten Schwarz and Christiana Ruhrberg
Role of the neuropilin ligands VEGF164 and SEMA3A in neuronal and vascular patterning in the mouse 230
Discussion 235
Final discussion 238
Tracheal tube development in Drosophila 238
Closing remarks 240
Contributor index 242
Subject index 244
Об авторе
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.
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