Gregory R. Bock & Jamie A. Goode 
Tinkering [PDF ebook] 
The Microevolution of Development

Much recent research in evolutionary developmental biology has
focused on the origin of new body plans. However, most evolutionary
change at the population and species level consists of tinkering:
small-scale alterations in developmental pathways within a single
body plan. Such microevolutionary events have been well studied on
a population genetic level and from the perspective of adaptive
phenotypic evolution, but their developmental mechanisms remain
poorly studied.

This book explores both theoretical and practical issues of
tinkering. It features a wide range of perspectives to address
several fundamental questions. How does tinkering occur
developmentally, and how is it manifested phenotypically? Are the
developmental mechanisms by which tinkering occur different from
those that underlie larger evolutionary changes? What are the
developmental constraints on tinkering? And how do we test
hypotheses about microevolutionary shifts in development from the
fossil record?

With contributions from experts in a range of fields, this
fascinating book makes exciting reading for anyone studying
evolution, developmental biology or genetics.

Содержание

Symposium on Tinkering: the microevolution of development, held at
the Novartis Foundation, London, 11-13 July 2006.

Editors: Gregory Bock (Organizer) and Jamie Goode.

This symposium is based on a proposal made by Brian Hall.

Daniel E. Lieberman The evolutionary developmental biology of
tinkering: an introduction to the challenge.

Manfred D. Laubichler Tinkering: a conceptual and historical
evaluation

Discussion.

Rudolf A. Raff and Elizabeth C. Raff Tinkering: new embryos from
old-rapidly and cheaply.

Discussion.

James M. Cheverud The relationship between development and
evolution through heritable variation.

Discussion.

Adam S. Wilkins Genetic networks as transmitting and amplifying
devices for natural genetic tinkering.

Discussion.



Paul M. Brakefield Butterfly eyespot patterns and how
evolutionary tinkering yields diversity.

Discussion.

General discussion I.

Günter P. Wagner and Anna Marie Pyle Tinkering with
transcription factor proteins: the role of transcription factor
adaptation in developmental evolution.

Discussion.

Denis Duboule, Basile Tarchini, Jozsef Zàkàny and
Marie Kmita Tinkering with constraints in the evolution of the
vertebrate limb anterior-posterior polarity.

Discussion.

Irma Thesleff, Elina Järvinen and Marika Suomalainen
Affecting tooth morphology and renewal by fine-tuning the signals
mediating cell and tissue interactions.

Discussion.

General discussion II.

Benedikt Hallgrimsson, Daniel E. Lieberman, Nathan M. Young,
Trish Parsons and Steven Wat Evolution of covariance in the
mammalian skull.

Discussion.

David L. Stern The developmental genetics of
microevolution.

Discussion.

Jukka Jernvall and Isaac Salazar-Ciudad The economy of tinkering
mammalian teeth.

Discussion.

Michael A. Bell, Kaitlyn E. Ellis and Howard I. Sirotkin Pelvic
skeleton reduction and Pitx1 expression in threespine stickleback
populations.

Discussion.

Michael I. Coates, Marcello Ruta and Peter J. Wagner Using
patterns of fin and limb phylogeny to test
developmental-evolutionary scenarios.

Discussion.

Rebecca R. Ackermann Craniofacial variation and developmental
divergence in primate and human evolution.

Discussion.

Contributor Index.

Subject Index.

Об авторе

The Novartis Foundation is an international scientific and
educational charity which promotes the study and general knowledge
of science and in particular encourages international co-operation
in scientific research.

Chair: DANIEL LIEBERMAN, Harvard University, Cambridge,
USA