This work represents the first comprehensive publication in the innovative field of pharmacogenomics, a field which is set to revolutionize pharmaceutical research. In addition to renowned editors, the list of contributors is a ’who-is-who’ in the field. Broad coverage of all aspects of pharmacogenomics with a full presentation of applications to disease conditions is featured. Anyone involved in pharmaceutical research and drug development needs this book to keep up with this new and revolutionary approach
Innehållsförteckning
Introduction to Pharmacogenomics: Promises, Opportunities, and Limitations
The Human Genome
Turning SNPs into Useful Markers of Drug Response
Association Studies in Pharmacogenomics
Genomics Applications that Facilitate the Understanding of Drug Action and Toxicity
The Role of Pharmacogenomics in Drug Discovery and Therapeutics
Pharmacogenomics and Drug Design
The Pharmacogenomics of Human P-glycoprotein
Pharmacogenomics of Drug Transporters
Pharmacogenomics of Asthma Treatment
Endothelial Cells are Targets for Hydroxy Urea: Relevance to the Current Therapeutic Strategy in Sickle Cell Disease
Pharmacogenomics and Complex Cardiovascular Disease – Clinical Studies in Candidate Genes
Pharmacogenomics of Lipid-lowering Agents
Pharmacogenomics of Chemotherapeutic Agents in Cancer Treatment
Pharmacogenomics of the Blood-Brain Barrier
Pharmacogenomics and the Treatment of Neurological Disease
Pharmacogenomics of Neurodegenerative Diseases: Examples and Perspectives
Psychiatric Pharmacogenomics: Prediction of Treatment Outcomes in Schizophrenia
Pharmacogenomics of Major Depression and Antidepressant Treatment
Pharmacogenomics of Bipolar Disorder
Pharmacogenomics of Alcoholism
Pharmacogenomics of Tobacco Addiction
Pharmacogenomics of Opioid Systems
Ethnicity and Pharmacogenomics
Pharmacogenomics: Ensuring Equity Regarding Drugs Based on Genetic Difference
Translation of Vascular Proteomics into Individualized Therapeutics
Glossary of Key Terms in Molecu-lar Genetics of Pharmacogeno-mics
Index
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