This book offers a detailed review of the pathological and imaging features, diagnosis and treatment of Ig G4-Related Kidney Disease (Ig G4-RKD). Ig G4-related disease (Ig G4-RD), which is characterized by an elevated serum Ig G4 level and infiltration of systemic organs by Ig G4 positive plasma cells, is a newly recognized systemic disease. Diverse renal manifestations including specific tubulointerstitial nephritis, membranous nephropathy, and tumor-like urological diseases extending to the pelvis and urinary tract in Ig G4-RD have been reported and are recently attracting attention as Ig G4-RKD. In this book, leading researchers in the field present the latest insights into the broad spectrum of Ig G4-RKD characteristics. In addition, they provide a detailed explanation of the pathology of Ig G4-RKD including comparisons between the kidney and other affected organs, such as the lacrimal, salivary glands and pancreas in the histopathological section. Ig G4-Related Kidney Disease will have a major impact on future immunological and nephrological studies and offers a useful resource not only for nephrologists but also general physicians and investigators in related fields.
Table of Content
Part I. General Remarks.-
1. Ig G4-Related Disease: History and Overview.-
2. Ig G4-Related Disease: Pathological Features and Differential Diagnosis.-
3. Potential Pathways in The Pathogenesis of Ig G4-Related Disease.-
4. Does Ig G4-Related Disease Have an Autoimmune Basis?.-
5. Plasmablasts: A Promising Biomarker in Ig G4-RD.-
Part II. Features of Ig G4-Related Ridney Disease and Associated Conditions.-
6. Overview of Ig G4-Related Kidney Disease.-
7. Ig G4-Related Kidney Disease: Clinical and Laboratory Features.-
8. Imaging Findings.-
9. Characteristic Tubulointerstitial Nephritis in Ig G4-Related Kidney Disease.-
10. Electron Microscopic Findings.-
11. Ig G4-Related Kidney Disease: Pathological Features –Membranous Glomerulonephritis.-
12. Ig G4-Related Kidney Disease: Pathological Features –Other Glomerular Disease.-
13. Ig G4-Related k Kidney Diseases and Conditions: Renal Pelvic and Ureteral Diseases.-
14. Retroperitoneal Fibrosis/Periaortitis and Hydronephrosis.-
15. Other Urogenital Lesions (Testis, Paratesticular Lesion, Bladder, Prostate etc.).-
16. Characteristic Distribution of Inflammatory Lesions in Ig G4-Related Kidney Disease:
Findings from Autopsy Case Series.-
17. Diagnosis of Ig G4-Related Kidney Disease.-
18. Pathogenesis of Ig G4-Related Kidney Disease.-
Part III. Treatment of Ig G4-RD and Ig G4-RKD.-
19. Corticosteroid Therapy for Ig G4-Related Kidney Disease.-
20. Targeting the B Cell Lineage in Ig G4-Related Disease.-
Part IV. Differential Diagnosis of Ig G4-RKD.-
21. Differential Diagnosis of Ig G4-Related Tubulointerstitial Nephritis –An Overview.-
22. Differential Diagnosis (1): ANCA Associated Vasculitis.-
23. Differential Diagnosis (2): Castleman Disease.-
24. Differential Diagnosis (3): Sjögren Syndrome.-
25. Differential Diagnosis: Lupus Nephritis and Ig G4-Related Kidney Disease.-
Part V. Lessons from Cases.-
26. Multicentric Castleman’s Disease Mimicking Ig G4-Related Disease; A Case Report.-
27. A Case of Concurrent Ig G4-Related Kidney Disease and Lupus Nephritis.
About the author
Takao Saito, Emeritus Professor, Faculty of Medicine, Fukuoka University
John H. Stone, Massachusetts General Hospital
Hitoshi Nakashima, Division of Nephrology & Rheumatology, Department of Internal Medicine, Fukuoka University
Takako Saeki, Department of Internal Medicine, Nagaoka Red Cross Hospital
Mitsuhiro Kawano, Division of Rheumatology, Department of Internal Medicine, Kanazawa University
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