This book offers a detailed review of the pathological and imaging features, diagnosis and treatment of Ig G4-Related Kidney Disease (Ig G4-RKD). Ig G4-related disease (Ig G4-RD), which is characterized by an elevated serum Ig G4 level and infiltration of systemic organs by Ig G4 positive plasma cells, is a newly recognized systemic disease. Diverse renal manifestations including specific tubulointerstitial nephritis, membranous nephropathy, and tumor-like urological diseases extending to the pelvis and urinary tract in Ig G4-RD have been reported and are recently attracting attention as Ig G4-RKD. In this book, leading researchers in the field present the latest insights into the broad spectrum of Ig G4-RKD characteristics. In addition, they provide a detailed explanation of the pathology of Ig G4-RKD including comparisons between the kidney and other affected organs, such as the lacrimal, salivary glands and pancreas in the histopathological section. Ig G4-Related Kidney Disease will have a major impact on future immunological and nephrological studies and offers a useful resource not only for nephrologists but also general physicians and investigators in related fields.
Mục lục
Part I. General Remarks.-
1. Ig G4-Related Disease: History and Overview.-
2. Ig G4-Related Disease: Pathological Features and Differential Diagnosis.-
3. Potential Pathways in The Pathogenesis of Ig G4-Related Disease.-
4. Does Ig G4-Related Disease Have an Autoimmune Basis?.-
5. Plasmablasts: A Promising Biomarker in Ig G4-RD.-
Part II. Features of Ig G4-Related Ridney Disease and Associated Conditions.-
6. Overview of Ig G4-Related Kidney Disease.-
7. Ig G4-Related Kidney Disease: Clinical and Laboratory Features.-
8. Imaging Findings.-
9. Characteristic Tubulointerstitial Nephritis in Ig G4-Related Kidney Disease.-
10. Electron Microscopic Findings.-
11. Ig G4-Related Kidney Disease: Pathological Features –Membranous Glomerulonephritis.-
12. Ig G4-Related Kidney Disease: Pathological Features –Other Glomerular Disease.-
13. Ig G4-Related k Kidney Diseases and Conditions: Renal Pelvic and Ureteral Diseases.-
14. Retroperitoneal Fibrosis/Periaortitis and Hydronephrosis.-
15. Other Urogenital Lesions (Testis, Paratesticular Lesion, Bladder, Prostate etc.).-
16. Characteristic Distribution of Inflammatory Lesions in Ig G4-Related Kidney Disease:
Findings from Autopsy Case Series.-
17. Diagnosis of Ig G4-Related Kidney Disease.-
18. Pathogenesis of Ig G4-Related Kidney Disease.-
Part III. Treatment of Ig G4-RD and Ig G4-RKD.-
19. Corticosteroid Therapy for Ig G4-Related Kidney Disease.-
20. Targeting the B Cell Lineage in Ig G4-Related Disease.-
Part IV. Differential Diagnosis of Ig G4-RKD.-
21. Differential Diagnosis of Ig G4-Related Tubulointerstitial Nephritis –An Overview.-
22. Differential Diagnosis (1): ANCA Associated Vasculitis.-
23. Differential Diagnosis (2): Castleman Disease.-
24. Differential Diagnosis (3): Sjögren Syndrome.-
25. Differential Diagnosis: Lupus Nephritis and Ig G4-Related Kidney Disease.-
Part V. Lessons from Cases.-
26. Multicentric Castleman’s Disease Mimicking Ig G4-Related Disease; A Case Report.-
27. A Case of Concurrent Ig G4-Related Kidney Disease and Lupus Nephritis.
Giới thiệu về tác giả
Takao Saito, Emeritus Professor, Faculty of Medicine, Fukuoka University
John H. Stone, Massachusetts General Hospital
Hitoshi Nakashima, Division of Nephrology & Rheumatology, Department of Internal Medicine, Fukuoka University
Takako Saeki, Department of Internal Medicine, Nagaoka Red Cross Hospital
Mitsuhiro Kawano, Division of Rheumatology, Department of Internal Medicine, Kanazawa University
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