Following their own brilliant careers in haeme protein research, the outstanding scientists Jonathan and Beatrice Wittenberg continue to provide inspiration to the research community in the study of oxygen-binding proteins. Their research has provided the intellectual stimulus to bring together scientists from all over the world with the common goal of developing fascinating new ideas and performing innovative experiments.
This book is dedicated to Jonathan’s and Bea’s lifetime careers. It further illuminates the facts and ideas which dot the paths they traced in Biochemistry and Physiology, elaborating on how these landmark achievements were made and how the haeme proteins community still refers to them. With the field of haeme protein science such a flourishing area, the contributors to this book predict Jonathan and Bea, having played such a seminal role, will continue to be key figures for quite some time to come.
สารบัญ
Introduction: A Dedication to Beatrice and Jonathan Wittenberg.- Reflections on Beatrice and Jonathan Wittenberg.- The Wittenbergs: A Personal Appreciation.- A Crystallographer’s Perspective on the 2/2Hb Family.- The Phylogeny and Structural Properties of 2/2 Haemoglobins.- Reexamining Data from the Past Related to the Evolution of the Functional Properties of the Haemoglobins of the Teleost Fish.- Evolutionary Physiology of Oxygen Secretion in the Eye of Fishes of the Suborder Notothenioidei.- Mutagenic Studies on the Origins of the Root Effect.- Redox Reactions of Cross-linked Haemoglobins with Oxygen and Nitrite.- Bis-histidyl Ferric Adducts in Tetrameric Haemoglobins.- Cooperativity and Ligand-linked Polymerisation in Scapharca Tetrameric Haemoglobin.- Human Serum Haeme-albumin: An Allosteric ‘Chronosteric’ Protein.- T- and R-state Tertiary Relaxations in Sol-gel Encapsulated Haemoglobin.- From O2 Diffusion into Red Blood Cells to Ligand Pathways in Globins.- Myoglobin Strikes Back.- The Bilatarian Sea Urchin and the Radial Starlet Sea Anemone Globins Share Strong Homologies with Vertebrate Neuroglobins.- Whale Rider: The Co-occurrence of Haemoglobin and Haemocyanin in Cyamus scammoni.- Neuroglobin and Other Nerve Haemoglobins.- Ever Surprising Nematode Globins.- Microbial Haemoglobins: Proteins at the Crossroads of Oxygen and Nitric Oxide Metabolism.
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