Selective cytoplasmic organelle and protein targeting has long been thought to constitute the sole determinant of cell polarity and complexity. This view has been changed, however, by the discovery of differential subcellular RNA distribution patterns. Over the past decade it has become clear that selective m RNA sorting and translation contributes to an accumulation of cognate proteins at discrete cellular sites. In this book, various systems are discussed (e.g. Xenopus oocytes, mammalian brain, invertebrate nervous system) in terms of RNA trafficking, RNA-targeting sequences (cis-elements) and RNA-transporting proteins (trans-factors), activity-dependent translational regulation and the significance of the cytoskeleton for neuronal function and plasticity. It also discusses nucleocytoplasmic export of m RNA and viral RNA as another example of subcellular RNA kinesis.
Dietmar Richter
Cell Polarity and Subcellular RNA Localization [PDF ebook]
Cell Polarity and Subcellular RNA Localization [PDF ebook]
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Ngôn ngữ Anh ● định dạng PDF ● ISBN 9783540400257 ● Biên tập viên Dietmar Richter ● Nhà xuất bản Springer Berlin Heidelberg ● Được phát hành 2012 ● Có thể tải xuống 3 lần ● Tiền tệ EUR ● TÔI 6318057 ● Sao chép bảo vệ Adobe DRM
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