In somatic cells, DNA is normally wrapped around the histones octamer to forms nucleosomes that eventually give rise to a solenoid DNA structure. Unlike somatic cells, in mammalian sperm, the development of spermatids into mature spermatozoa is accomplished by a series of structural and chemical modifications including a gradual replacement of lysine-rich histones by transition proteins and then by protamines which bind more tightly to DNA than histones, which results in compaction of chromatin in the sperm nucleus, a process which is termed `sperm chromatin condensation’. This book examines the several techniques that have been devised in order to study chromatin and DNA defects in human spermatozoa.
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格式 PDF ● 网页 137 ● ISBN 9781616684952 ● 编辑 Ali Reza Talebi ● 出版者 Nova Science Publishers ● 发布时间 2016 ● 下载 3 时 ● 货币 EUR ● ID 7219443 ● 复制保护 Adobe DRM
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