Vaccinology: An Essential Guide outlines in a clear,
practical format the entire vaccine development process, from
conceptualization and basic immunological principles through to
clinical testing and licensing of vaccines. With an
outstanding introduction to the history and practice of
vaccinology, it also guides the reader through the basic science
relating to host immune responses to pathogens.
Covering the safety, regulatory, ethical, and economic
and geographical issues that drive vaccine development and trials,
it also presents vaccine delivery strategies, novel vaccine
platforms (including experimental vaccines and pathogens), antigen
development and selection, vaccine modelling, and the development
of vaccines against emerging pathogens and agents of bioterror.
There are also sections devoted to veterinary vaccines and
associated regulatory processes.
Vaccinology: An Essential Guide is a perfect tool for
designed for undergraduate and graduate microbiologists and
immunologists, as well as residents, fellows and trainees of
infectious disease and vaccinology. It is also suitable for all
those involved in designing and conducting clinical vaccine trials,
and is the ideal companion to the larger reference book
Vaccinology: Principles and Practice.
Tabella dei contenuti
Contributors vii
Preface ix
1 The history of vaccine development and the diseases vaccines prevent 1
Martin G. Myers
2 The vaccine development pathway 33
David W.C. Beasley
3 Control and eradication of human and animal diseases by vaccination 43
Nigel Bourne and Gregg N. Milligan
4 Pathogenesis of infectious diseases and mechanisms of immunity 59
Jere W. Mc Bride and David H. Walker
5 The host immune response protective immunity and correlates of protection 73
Gregg N. Milligan
6 Adjuvants: making vaccines immunogenic 93
Gregg N. Milligan
7 Discovery and the basic science phase of vaccine development 109
Gavin C. Bowick
8 Microbial-based and material-based vaccine delivery systems 127
Alfredo G. Torres, Jai S. Rudra and Gregg N. Milligan
9 Licensed vaccines for humans 152
Alan D.T. Barrett
10 Veterinary vaccines 181
A. Paige Adams
11 Development of vaccines for microbial diseases 192
Dennis W. Trent and David W.C. Beasley
12 The regulatory path to vaccine licensure 212
Dennis W. Trent
13 Veterinary vaccines: regulations and impact on emerging infectious diseases 232
A. Paige Adams
14 Vaccine manufacturing 243
Dirk E. Teuwen and Alan D.T. Barrett
15 Clinical evaluation of vaccines 260
Richard E. Rupp and Bridget E. Hawkins
16 Vaccine recommendations and special populations 273
Richard E. Rupp and Bridget E. Hawkins
17 Vaccine safety 287
Dirk E. Teuwen and Alan D.T. Barrett
18 Understanding and measuring the dynamics of infectious disease transmission 304
Christine M. Arcari
19 Vaccines from a global perspective 319
Alan D.T. Barrett and Bridget E. Hawkins
20 Political ethical social and psychological aspects of vaccinology 335
Caroline M. Poland, Robert M. Jacobson, Douglas J. Opel, Edgar K. Marcuse and Gregory A. Poland
Index 358
Circa l’autore
Alan D.T. Barrett, Ph.D., Professor, Department of Pathology, John D. Stobo, M.D. Chair in Vacinology and Director, Sealy Center for Vaccine Development, University of Texas Medical Branch at Galveston, Texas, USA
Gregg N. Milligan, Professor, Department of Pediatrics and Senior Scientist, Sealy Center for Vaccine Development, University of Texas Medical Branch at Galveston, Texas, USA
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