There is an urgent need to uncover new therapies that will protect
against malaria, as the parasite becomes increasingly resistant to
available drugs and this book offers insights into three
interrelated aspects of the malaria-infected erythrocyte:
* The transport of solutes into and out of the infected cell and
the use of specific trafficking pathways in drug targeting
* The traffic of proteins produced by the intracellular parasite as
an essential process for the biogenesis of transport systems.
* The relationship between the transport of drugs into the infected
cell and the mode of drug action and drug resistance.
Tabella dei contenuti
Introduction: host-parasite interrelations in the genomic age
H. GINSBURG
Erythrocyte membrane transport
Z. I. CABANTCHIK
Chemical and physical in vitro alterations of the erythrocyte
membrane: a model for its pathophysiological states?
B. DEUTICKE
The effects of transport perturbations on the homeostasis of red
blood cells
V. LEW and A.R. HOCKADAY
Transport properties of the host cell membrane
K. KIRK, H.M. STAINES, R.E. MARTIN and K.J. SALIBA
Transport of phospholipid synthesis precursors and lipid
trafficking into malaria-infected erythrocytes
H.J. VIAL, P. ELDIN, D. MARTIN, L. GANNOUN, M. CALAS and M.L.
ANCELIN
A nutrient-permeable channel on the intraerythrocytic malaria
parasite
S.A. DESAI
The permeability properties of the parasite cell membrane
H. GINSBURG
Macromolecular transport in malaria-infected erythrocytes
T. F. TARASCHI
Expression of parasite transporters in Xenopus oocytes
S. KRISHNA and C.J. WOODROW
Reconstitution of protein transport across the vacuolar membrane
in Plasmodium falciparum-infected permeabilized erythrocytes
S. BAUMEISTER, A. BURGWEDEL, U.-G. MAIER and K. LINGELBACH
Export of parasite proteins to the erythrocyte cytoplasm:
secretory machinery and signalling motifs
F.R. ALBANO, M. FOLEY and L. TILLEY
Transport and trafficking: Toxoplasma as a model for
Plasmodium
D.S. ROOS, M.J. CRAWFORD, R.G.K. DONALD, L.M. FOHL, K.M. HAGER,
J.C. KISSINGER, M.G. REYNOLDS, B. STREIPEN and W.J. SULLIVAN Jr
An alternative secretory pathway in Plasmodium: more questions
than answers
M.F. WISER, D.J. GRAB, and H.N. LANNERS
The transport of the histidine-rich protein I from Plasmodium
falciparum is insensitive to brefeldin A
D. MATTEI, L. BERRY, S. COUFFIN and O. RICHARD
Protein transport in the host cell cytoplasm and ATP-binding
cassette proteins in Plasmodium falciparum-infected
erythrocytes
Z. BOZDECH and E. SCHURR
Chloroquine uptake and activity is determined by binding to
ferriprotoporphyrin IX in Plasmodium faciparum
P.G. BRAY, O. JANNEH and S.A. WARD
Chloroquine uptake, altered partiitioning and the basis of drug
resistance: evidence for chloride dependent ionic regulation
J.A. MARTINEY, A.S. FERRER, A. CERAMI, S. DZEKUNOV and P.
ROEPE
Circa l’autore
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.
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